ITA4_HUMAN » Integrin alpha-4

ITA4_HUMAN » Integrin alpha-4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITA4_HUMAN » Integrin alpha-4 » CD49 antigen-like family member D;Integrin alpha-IV;VLA-4 subunit alpha;
Hydrophobic Thickness 36.0 ± 2.6 Å
Tilt Angle 0 ± 4°
ΔGtransfer -42.2 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 975- 999 (970-1002)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Cell adhesion molecules (KEGG)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Focal adhesion (KEGG)

Hematopoietic cell lineage (KEGG)

Hemostasis (Reactome)

Hypertrophic cardiomyopathy (KEGG)

Immune System (Reactome)

Intestinal immune network for IgA production (KEGG)

Leishmaniasis (KEGG)

Leukocyte transendothelial migration (KEGG)

PI3K-Akt signaling pathway (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB 3v4p (A/C=34-620), 3v4v (A/C=34-620), 4hkc (B=1003-1032)
OPM none
Complexes

ITB7:ITA4_HUMAN

Interactions

ADA28, Complex: ITA4:ADA28, PubMed

ADAM2, Complex: ITB1:ITA4:ADAM2, PubMed

ATD3A, Complex: ITA4:ATD3A, PubMed

CD44, Complex: ITA4:CD44, PubMed

CLIC1, Complex: ITA4:CLIC1, PubMed

ESYT1, Complex: ITA4:ESYT1, PubMed

FCG2A, Complex: FCG2A:ITA4, PubMed

FCG2C, Complex: FCG2C:ITA4, PubMed

ICAM4, Complex: ICAM4:ITA4, PubMed

IMMT, Complex: IMMT:ITA4, PubMed

ITB1, Complex: ITB1:TSP1:ITA4, PubMed

ITB7, Complex: ITB7:ITA4, PDBID: 3v4p, PubMed

JAM2, Complex: ITB1:JAM2:ITA4, PubMed

LRC59, Complex: LRC59:ITA4, PubMed

MADCA, Complex: ITA4:MADCA, PubMed

PO210, Complex: PO210:ITA4, PubMed

SC61B, Complex: ITA4:SC61B, PubMed

TFR1, Complex: TFR1:ITA4, PubMed

VAMP8, Complex: ITA4:VAMP8, PubMed

VAPA, Complex: ITA4:VAPA, PubMed

VCAM1, Complex: VCAM1:ITA4, PubMed

Domains

AA: 306-342, PDBID: 3V4P, Subunit C, Seq Identity:100%, FG-GAP repeat

AA: 369-403, PDBID: 3V4P, Subunit C, Seq Identity:100%, FG-GAP repeat

AA: 463-906, PDBID: 3V4P, Subunit C, Seq Identity:100%, Integrin alpha

UniProt annotation for ITA4_HUMAN » Integrin alpha-4
FUNCTION: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Interacts with AMICA1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1 homodimerization.

DOMAIN: The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.

UniProt features for ITA4_HUMAN » Integrin alpha-4
SIGNAL 1 33
CHAIN 34 1032 Integrin alpha-4.
REPEAT 35 100 FG-GAP 1.
REPEAT 110 177 FG-GAP 2.
REPEAT 185 237 FG-GAP 3.
REPEAT 238 293 FG-GAP 4.
REPEAT 294 351 FG-GAP 5.
REPEAT 355 412 FG-GAP 6.
REPEAT 416 478 FG-GAP 7.
MOTIF 606 616 SG1.
MOTIF 1003 1007 GFFKR motif.
SITE 591 592 Cleavage.
DISULFID 91 101 By similarity.
DISULFID 144 165 By similarity.
DISULFID 183 198 By similarity.
DISULFID 486 495 By similarity.
DISULFID 501 557 By similarity.
DISULFID 622 627 By similarity.
DISULFID 698 711 By similarity.
DISULFID 852 890 By similarity.
DISULFID 897 902 By similarity.
Amino Acid Sequence for ITA4_HUMAN » Integrin alpha-4
MAWEARREPG PRRAAVRETV MLLLCLGVPT GRPYNVDTES ALLYQGPHNT LFGYSVVLHS HGANRWLLVG APTANWLANA SVINPGAIYR CRIGKNPGQT CEQLQLGSPN GEPCGKTCLE ERDNQWLGVT LSRQPGENGS IVTCGHRWKN IFYIKNENKL PTGGCYGVPP DLRTELSKRI APCYQDYVKK FGENFASCQA GISSFYTKDL IVMGAPGSSY WTGSLFVYNI TTNKYKAFLD KQNQVKFGSY LGYSVGAGHF RSQHTTEVVG GAPQHEQIGK AYIFSIDEKE LNILHEMKGK KLGSYFGASV CAVDLNADGF SDLLVGAPMQ STIREEGRVF VYINSGSGAV MNAMETNLVG SDKYAARFGE SIVNLGDIDN DGFEDVAIGA PQEDDLQGAI YIYNGRADGI SSTFSQRIEG LQISKSLSMF GQSISGQIDA DNNGYVDVAV GAFRSDSAVL LRTRPVVIVD ASLSHPESVN RTKFDCVENG WPSVCIDLTL CFSYKGKEVP GYIVLFYNMS LDVNRKAESP PRFYFSSNGT SDVITGSIQV SSREANCRTH QAFMRKDVRD ILTPIQIEAA YHLGPHVISK RSTEEFPPLQ PILQQKKEKD IMKKTINFAR FCAHENCSAD LQVSAKIGFL KPHENKTYLA VGSMKTLMLN VSLFNAGDDA YETTLHVKLP VGLYFIKILE LEEKQINCEV TDNSGVVQLD CSIGYIYVDH LSRIDISFLL DVSSLSRAEE DLSITVHATC ENEEEMDNLK HSRVTVAIPL KYEVKLTVHG FVNPTSFVYG SNDENEPETC MVEKMNLTFH VINTGNSMAP NVSVEIMVPN SFSPQTDKLF NILDVQTTTG ECHFENYQRV CALEQQKSAM QTLKGIVQFL SKTDKRLLYC IKADPHCLNF LCNFGKMESG KEASVHIQLE GRPSILEMDE TSALKFEIRA TGFPEPNPRV IELNKDENVA HVLLEGLHHQ RPKRYFTIVI ISSSLLLGLI VLLLISYVMW KAGFFKRQYK SILQEENRRD SWSYINSKSN DD