ITA2_HUMAN » Integrin alpha-2

ITA2_HUMAN » Integrin alpha-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITA2_HUMAN » Integrin alpha-2 » CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa; VLA-2 subunit alpha;
Hydrophobic Thickness 34.0 ± 2.6 Å
Tilt Angle 49 ± 0°
ΔGtransfer -28.8 kcal/mol
ΔGfold -25.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1131-1160 (1131-1167)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Developmental Biology (Reactome)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Focal adhesion (KEGG)

Hematopoietic cell lineage (KEGG)

Hemostasis (Reactome)

Hypertrophic cardiomyopathy (KEGG)

Pathways in cancer (KEGG)

Phagosome (KEGG)

PI3K-Akt signaling pathway (KEGG)

Proteoglycans in cancer (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

Small cell lung cancer (KEGG)

PDB 1aox (A/B=169-367), 4bj3 (A/B=171-368), 1dzi (A=172-355), 1v7p (C=167-366)
OPM none
Complexes none
Interactions

AUP1, Complex: AUP1:ITA2, PubMed

ITB1, Complex: CHAD:ITB1:ITA2, PubMed

ITB3, Complex: ITB3:CD9:ITA2, PubMed

MCP, Complex: ITA2:MCP, PubMed

VGFR2, Complex: VGFR2:ITA2

Domains

AA: 174-355, PDBID: 1AOX, Subunit A, Seq Identity:100%, von Willebrand factor type A domain

AA: 491-530, PDBID: 3K6S, Subunit E, Seq Identity:45%, FG-GAP repeat

AA: 554-589, PDBID: 3K6S, Subunit E, Seq Identity:53%, FG-GAP repeat

AA: 649-1068, PDBID: 3VI3, Subunit A, Seq Identity:21%, Integrin alpha

UniProt annotation for ITA2_HUMAN » Integrin alpha-2
FUNCTION: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor.

DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

UniProt features for ITA2_HUMAN » Integrin alpha-2
SIGNAL 1 29
CHAIN 30 1181 Integrin alpha-2.
REPEAT 34 92 FG-GAP 1.
REPEAT 101 161 FG-GAP 2.
DOMAIN 188 365 VWFA.
REPEAT 366 420 FG-GAP 3.
REPEAT 423 477 FG-GAP 4.
REPEAT 478 539 FG-GAP 5.
REPEAT 540 598 FG-GAP 6.
REPEAT 602 664 FG-GAP 7.
REGION 1155 1161 Interaction with HPS5.
MOTIF 1157 1161 GFFKR motif.
DISULFID 83 92 By similarity.
DISULFID 680 737 By similarity.
DISULFID 789 795 By similarity.
DISULFID 865 876 By similarity.
DISULFID 1019 1050 By similarity.
DISULFID 1055 1060 By similarity.
Amino Acid Sequence for ITA2_HUMAN » Integrin alpha-2
MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY AVQQFINPKG NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS TSIPNVTEMK TNMSLGLILT RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS DISPDFQLSA SFSPATQPCP SLIDVVVVCD ESNSIYPWDA VKNFLEKFVQ GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS QTSQYGGDLT NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL LEKAGTLGEQ IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG AFGWSGTIVQ KTSHGHLIFP KQAFDQILQD RNHSSYLGYS VAAISTGEST HFVAGAPRAN YTGQIVLYSV NENGNITVIQ AHRGDQIGSY FGSVLCSVDV DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKKGILGQH QFLEGPEGIE NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ SIADVAIEAS FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI TLDADGFSSR VTSRGLFKEN NERCLQKNMV VNQAQSCPEH IIYIQEPSDV VNSLDLRVDI SLENPGTSPA LEAYSETAKV FSIPFHKDCG EDGLCISDLV LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG IVVDFSENLF FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TRSTNINFYE ISSDGNVPSI VHSFEDVGPK FIFSLKVTTG SVPVSMATVI IHIPQYTKEK NPLMYLTGVQ TDKAGDISCN ADINPLKIGQ TSSSVSFKSE NFRHTKELNC RTASCSNVTC WLKDVHMKGE YFVNVTTRIW NGTFASSTFQ TVQLTAAAEI NTYNPEIYVI EDNTVTIPLM IMKPDEKAEV PTGVIIGSII AGILLLLALV AILWKLGFFK RKYEKMTKNP DEIDETTELS S