ITA11_HUMAN » Integrin alpha-11

ITA11_HUMAN » Integrin alpha-11
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITA11_HUMAN » Integrin alpha-11 »
Hydrophobic Thickness 34.4 ± 5.0 Å
Tilt Angle 30 ± 3°
ΔGtransfer -25.8 kcal/mol
ΔGfold -22.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1145-1171 (1140-1176)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Focal adhesion (KEGG)

Hypertrophic cardiomyopathy (KEGG)

PI3K-Akt signaling pathway (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

ITB1, Complex: ITA11:ITB1, PubMed

Domains

AA: 164-344, PDBID: 1PT6, Subunit B, Seq Identity:61%, von Willebrand factor type A domain

AA: 480-518, PDBID: 3K6S, Subunit E, Seq Identity:46%, FG-GAP repeat

AA: 542-577, PDBID: 3K6S, Subunit E, Seq Identity:51%, FG-GAP repeat

AA: 635-1067, PDBID: 1TYE, Subunit C, Seq Identity:22%, Integrin alpha

UniProt annotation for ITA11_HUMAN » Integrin alpha-11
FUNCTION: Integrin alpha-11/beta-1 is a receptor for collagen.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21.

TISSUE SPECIFICITY: According to PubMed, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver.

DEVELOPMENTAL STAGE: Strongly up-regulated in differentiating fetal muscle cells (in vitro).

DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

UniProt features for ITA11_HUMAN » Integrin alpha-11
SIGNAL 1 22 Potential.
CHAIN 23 1188 Integrin alpha-11.
REPEAT 24 85 FG-GAP 1.
REPEAT 91 151 FG-GAP 2.
DOMAIN 164 345 VWFA.
REPEAT 355 406 FG-GAP 3.
REPEAT 411 466 FG-GAP 4.
REPEAT 467 527 FG-GAP 5.
REPEAT 528 586 FG-GAP 6.
REPEAT 590 650 FG-GAP 7.
DISULFID 76 83 By similarity.
DISULFID 121 139 Potential.
DISULFID 129 159 Potential.
DISULFID 659 668 By similarity.
DISULFID 674 729 By similarity.
DISULFID 781 787 By similarity.
DISULFID 881 893 By similarity.
Amino Acid Sequence for ITA11_HUMAN » Integrin alpha-11
MDLPRGLVVA WALSLWPGFT DTFNMDTRKP RVIPGSRTAF FGYTVQQHDI SGNKWLVVGA PLETNGYQKT GDVYKCPVIH GNCTKLNLGR VTLSNVSERK DNMRLGLSLA TNPKDNSFLA CSPLWSHECG SSYYTTGMCS RVNSNFRFSK TVAPALQRCQ TYMDIVIVLD GSNSIYPWVE VQHFLINILK KFYIGPGQIQ VGVVQYGEDV VHEFHLNDYR SVKDVVEAAS HIEQRGGTET RTAFGIEFAR SEAFQKGGRK GAKKVMIVIT DGESHDSPDL EKVIQQSERD NVTRYAVAVL GYYNRRGINP ETFLNEIKYI ASDPDDKHFF NVTDEAALKD IVDALGDRIF SLEGTNKNET SFGLEMSQTG FSSHVVEDGV LLGAVGAYDW NGAVLKETSA GKVIPLRESY LKEFPEELKN HGAYLGYTVT SVVSSRQGRV YVAGAPRFNH TGKVILFTMH NNRSLTIHQA MRGQQIGSYF GSEITSVDID GDGVTDVLLV GAPMYFNEGR ERGKVYVYEL RQNRFVYNGT LKDSHSYQNA RFGSSIASVR DLNQDSYNDV VVGAPLEDNH AGAIYIFHGF RGSILKTPKQ RITASELATG LQYFGCSIHG QLDLNEDGLI DLAVGALGNA VILWSRPVVQ INASLHFEPS KINIFHRDCK RSGRDATCLA AFLCFTPIFL APHFQTTTVG IRYNATMDER RYTPRAHLDE GGDRFTNRAV LLSSGQELCE RINFHVLDTA DYVKPVTFSV EYSLEDPDHG PMLDDGWPTT LRVSVPFWNG CNEDEHCVPD LVLDARSDLP TAMEYCQRVL RKPAQDCSAY TLSFDTTVFI IESTRQRVAV EATLENRGEN AYSTVLNISQ SANLQFASLI QKEDSDGSIE CVNEERRLQK QVCNVSYPFF RAKAKVAFRL DFEFSKSIFL HHLEIELAAG SDSNERDSTK EDNVAPLRFH LKYEADVLFT RSSSLSHYEV KLNSSLERYD GIGPPFSCIF RIQNLGLFPI HGIMMKITIP IATRSGNRLL KLRDFLTDEV ANTSCNIWGN STEYRPTPVE EDLRRAPQLN HSNSDVVSIN CNIRLVPNQE INFHLLGNLW LRSLKALKYK SMKIMVNAAL QRQFHSPFIF REEDPSRQIV FEISKQEDWQ VPIWIIVGST LGGLLLLALL VLALWKLGFF RSARRRREPG LDPTPKVLE