ITA10_HUMAN » Integrin alpha-10

ITA10_HUMAN » Integrin alpha-10
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITA10_HUMAN » Integrin alpha-10 »
Hydrophobic Thickness 34.4 ± 0.8 Å
Tilt Angle 24 ± 0°
ΔGtransfer -54.4 kcal/mol
ΔGfold -23.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1119-1151 (1119-1153)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Focal adhesion (KEGG)

Hypertrophic cardiomyopathy (KEGG)

PI3K-Akt signaling pathway (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

ITB1, Complex: ITB1:ITA10, PubMed

Domains

AA: 167-349, PDBID: 1PT6, Subunit B, Seq Identity:51%, von Willebrand factor type A domain

AA: 486-525, PDBID: 1TYE, Subunit C, Seq Identity:42%, FG-GAP repeat

AA: 549-584, PDBID: 3K6S, Subunit E, Seq Identity:53%, FG-GAP repeat

AA: 642-1059, PDBID: 3VI3, Subunit A, Seq Identity:24%, Integrin alpha

UniProt annotation for ITA10_HUMAN » Integrin alpha-10
FUNCTION: Integrin alpha-10/beta-1 is a receptor for collagen.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.

TISSUE SPECIFICITY: Widely expressed with highest expression in muscle and heart. Found in articular cartilage.

DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

UniProt features for ITA10_HUMAN » Integrin alpha-10
SIGNAL 1 22 Potential.
CHAIN 23 1167 Integrin alpha-10.
REPEAT 24 85 FG-GAP 1.
REPEAT 95 154 FG-GAP 2.
DOMAIN 167 350 VWFA.
REPEAT 361 412 FG-GAP 3.
REPEAT 417 472 FG-GAP 4.
REPEAT 473 534 FG-GAP 5.
REPEAT 535 593 FG-GAP 6.
REPEAT 597 657 FG-GAP 7.
DISULFID 76 86 By similarity.
DISULFID 666 675 By similarity.
DISULFID 681 736 By similarity.
DISULFID 789 795 By similarity.
Amino Acid Sequence for ITA10_HUMAN » Integrin alpha-10
MELPFVTHLF LPLVFLTGLC SPFNLDEHHP RLFPGPPEAE FGYSVLQHVG GGQRWMLVGA PWDGPSGDRR GDVYRCPVGG AHNAPCAKGH LGDYQLGNSS HPAVNMHLGM SLLETDGDGG FMACAPLWSR ACGSSVFSSG ICARVDASFQ PQGSLAPTAQ RCPTYMDVVI VLDGSNSIYP WSEVQTFLRR LVGKLFIDPE QIQVGLVQYG ESPVHEWSLG DFRTKEEVVR AAKNLSRREG RETKTAQAIM VACTEGFSQS HGGRPEAARL LVVVTDGESH DGEELPAALK ACEAGRVTRY GIAVLGHYLR RQRDPSSFLR EIRTIASDPD ERFFFNVTDE AALTDIVDAL GDRIFGLEGS HAENESSFGL EMSQIGFSTH RLKDGILFGM VGAYDWGGSV LWLEGGHRLF PPRMALEDEF PPALQNHAAY LGYSVSSMLL RGGRRLFLSG APRFRHRGKV IAFQLKKDGA VRVAQSLQGE QIGSYFGSEL CPLDTDRDGT TDVLLVAAPM FLGPQNKETG RVYVYLVGQQ SLLTLQGTLQ PEPPQDARFG FAMGALPDLN QDGFADVAVG APLEDGHQGA LYLYHGTQSG VRPHPAQRIA AASMPHALSY FGRSVDGRLD LDGDDLVDVA VGAQGAAILL SSRPIVHLTP SLEVTPQAIS VVQRDCRRRG QEAVCLTAAL CFQVTSRTPG RWDHQFYMRF TASLDEWTAG ARAAFDGSGQ RLSPRRLRLS VGNVTCEQLH FHVLDTSDYL RPVALTVTFA LDNTTKPGPV LNEGSPTSIQ KLVPFSKDCG PDNECVTDLV LQVNMDIRGS RKAPFVVRGG RRKVLVSTTL ENRKENAYNT SLSLIFSRNL HLASLTPQRE SPIKVECAAP SAHARLCSVG HPVFQTGAKV TFLLEFEFSC SSLLSQVFVK LTASSDSLER NGTLQDNTAQ TSAYIQYEPH LLFSSESTLH RYEVHPYGTL PVGPGPEFKT TLRVQNLGCY VVSGLIISAL LPAVAHGGNY FLSLSQVITN NASCIVQNLT EPPGPPVHPE ELQHTNRLNG SNTQCQVVRC HLGQLAKGTE VSVGLLRLVH NEFFRRAKFK SLTVVSTFEL GTEEGSVLQL TEASRWSESL LEVVQTRPIL ISLWILIGSV LGGLLLLALL VFCLWKLGFF AHKKIPEEEK REEKLEQ