ISLR2_HUMAN » Immunoglobulin superfamily containing leucine-rich repeat protein 2

ISLR2_HUMAN » Immunoglobulin superfamily containing leucine-rich repeat protein 2
Magnify ISLR2_HUMAN » Immunoglobulin superfamily containing leucine-rich repeat protein 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ISLR2_HUMAN » Immunoglobulin superfamily containing leucine-rich repeat protein 2 » Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein;
Hydrophobic Thickness 40.0 ± 5.2 Å
Tilt Angle 39 ± 8°
ΔGtransfer -29.9 kcal/mol
ΔGfold -20.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 586-618 (586-620)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 51-111, PDBID: 2V70, Subunit C, Seq Identity:38%, Leucine rich repeat

AA: 123-183, PDBID: 2V9S, Subunit C, Seq Identity:43%, Leucine rich repeat

UniProt annotation for ISLR2_HUMAN » Immunoglobulin superfamily containing leucine-rich repeat protein 2
FUNCTION: Required for axon extension during neural development.

SUBUNIT: Homomultimer. Interacts with NTRK1/TrkA (By similarity).

UniProt features for ISLR2_HUMAN » Immunoglobulin superfamily containing leucine-rich repeat protein 2
SIGNAL 1 18 Potential.
CHAIN 19 745 Immunoglobulin superfamily containing leucine-rich repeat protein 2.
DOMAIN 19 51 LRRNT.
REPEAT 52 73 LRR 1.
REPEAT 76 97 LRR 2.
REPEAT 100 123 LRR 3.
REPEAT 124 145 LRR 4.
REPEAT 148 169 LRR 5.
DOMAIN 181 232 LRRCT.
DOMAIN 233 371 Ig-like.
DISULFID 260 355 By similarity.
Amino Acid Sequence for ISLR2_HUMAN » Immunoglobulin superfamily containing leucine-rich repeat protein 2
MFPLRALWLV WALLGVAGSC PEPCACVDKY AHQFADCAYK ELREVPEGLP ANVTTLSLSA NKITVLRRGA FADVTQVTSL WLAHNEVRTV EPGALAVLSQ LKNLDLSHNF ISSFPWSDLR NLSALQLLKM NHNRLGSLPR DALGALPDLR SLRINNNRLR TLAPGTFDAL SALSHLQLYH NPFHCGCGLV WLQAWAASTR VSLPEPDSIA CASPPALQGV PVYRLPALPC APPSVHLSAE PPLEAPGTPL RAGLAFVLHC IADGHPTPRL QWQLQIPGGT VVLEPPVLSG EDDGVGAEEG EGEGDGDLLT QTQAQTPTPA PAWPAPPATP RFLALANGSL LVPLLSAKEA GVYTCRAHNE LGANSTSIRV AVAATGPPKH APGAGGEPDG QAPTSERKST AKGRGNSVLP SKPEGKIKGQ GLAKVSILGE TETEPEEDTS EGEEAEDQIL ADPAEEQRCG NGDPSRYVSN HAFNQSAELK PHVFELGVIA LDVAEREARV QLTPLAARWG PGPGGAGGAP RPGRRPLRLL YLCPAGGGAA VQWSRVEEGV NAYWFRGLRP GTNYSVCLAL AGEACHVQVV FSTKKELPSL LVIVAVSVFL LVLATVPLLG AACCHLLAKH PGKPYRLILR PQAPDPMEKR IAADFDPRAS YLESEKSYPA GGEAGGEEPE DVQGEGLDED AEQGDPSGDL QREESLAACS LVESQSKANQ EEFEAGSEYS DRLPLGAEAV NIAQEINGNY RQTAG