IRPL2_HUMAN » X-linked interleukin-1 receptor accessory protein-like 2

IRPL2_HUMAN » X-linked interleukin-1 receptor accessory protein-like 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IRPL2_HUMAN » X-linked interleukin-1 receptor accessory protein-like 2 » IL-1 receptor accessory protein-like 2; IL-1-RAPL-2; IL-1RAPL-2; IL1RAPL-2; IL1RAPL-2-related protein;Interleukin-1 receptor 9;IL-1R-9; IL-1R9; Three immunoglobulin domain-containing IL-1 receptor-related 1;TIGIRR-1;
Hydrophobic Thickness 34.0 ± 2.6 Å
Tilt Angle 30 ± 1°
ΔGtransfer -26.6 kcal/mol
ΔGfold -20.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 351-376 (351-378)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 143-231, PDBID: 4YFD, Subunit B, Seq Identity:29%, Immunoglobulin domain

AA: 249-345, PDBID: 4YFC, Subunit B, Seq Identity:47%, Immunoglobulin domain

AA: 402-575, PDBID: 1T3G, Subunit B, Seq Identity:59%, TIR domain

UniProt annotation for IRPL2_HUMAN » X-linked interleukin-1 receptor accessory protein-like 2
TISSUE SPECIFICITY: Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta.
UniProt features for IRPL2_HUMAN » X-linked interleukin-1 receptor accessory protein-like 2
SIGNAL 1 16 Potential.
CHAIN 17 686 X-linked interleukin-1 receptor accessory protein-like 2.
DOMAIN 18 132 Ig-like C2-type 1.
DOMAIN 141 232 Ig-like C2-type 2.
DOMAIN 239 347 Ig-like C2-type 3.
DOMAIN 400 559 TIR.
DISULFID 53 116 Potential.
DISULFID 162 214 Potential.
DISULFID 265 331 Potential.
Amino Acid Sequence for IRPL2_HUMAN » X-linked interleukin-1 receptor accessory protein-like 2
MKPPFLLALV VCSVVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR VKCALFYSYI RTNYSTAQST GLRLMWYKNK GDLEEPIIFS EVRMSKEEDS IWFHSAEAQD SGFYTCVLRN STYCMKVSMS LTVAENESGL CYNSRIRYLE KSEVTKRKEI SCPDMDDFKK SDQEPDVVWY KECKPKMWRS IIIQKGNALL IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP KPLFPMENQP SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI RLLKEHLGEK EVELALIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD LIYKIELAGG LGAIFLLLVL LVVIYKCYNI ELMLFYRQHF GADETNDDNK EYDAYLSYTK VDQDTLDCDN PEEEQFALEV LPDVLEKHYG YKLFIPERDL IPSGTYMEDL TRYVEQSRRL IIVLTPDYIL RRGWSIFELE SRLHNMLVSG EIKVILIECT ELKGKVNCQE VESLKRSIKL LSLIKWKGSK SSKLNSKFWK HLVYEMPIKK KEMLPRCHVL DSAEQGLFGE LQPIPSIAMT STSATLVSSQ ADLPEFHPSD SMQIRHCCRG YKHEIPATTL PVPSLGNHHT YCNLPLTLLN GQLPLNNTLK DTQEFHRNSS LLPLSSKELS FTSDIW