IREA_DICDI » Probable serine/threonine-protein kinase ireA

IREA_DICDI » Probable serine/threonine-protein kinase ireA
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IREA_DICDI » Probable serine/threonine-protein kinase ireA » Inositol-requiring protein A;
Hydrophobic Thickness 28.2 ± 3.3 Å
Tilt Angle 3 ± 7°
ΔGtransfer -16.0 kcal/mol
ΔGfold -14.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 441-460 (438-461)
Pathways

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 575-851, PDBID: 3P23, Subunit A, Seq Identity:52%, Protein kinase domain

AA: 857-983, PDBID: 2RIO, Subunit A, Seq Identity:41%, Ribonuclease 2-5A

UniProt annotation for IREA_DICDI » Probable serine/threonine-protein kinase ireA
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
UniProt features for IREA_DICDI » Probable serine/threonine-protein kinase ireA
SIGNAL 1 26 Potential.
CHAIN 27 984 Probable serine/threonine-protein kinase ireA.
DOMAIN 575 851 Protein kinase.
DOMAIN 854 984 KEN.
COILED 467 533 Potential.
ACT_SITE 722 722 Proton acceptor (By similarity).
Amino Acid Sequence for IREA_DICDI » Probable serine/threonine-protein kinase ireA
MTFSKTRNKI IFLLFLIIIN IFNINAYIKD ENEDDLSLLI STLDGNIYSF NYESGELNWD LKPNGGDSLY STSQFDRKQQ QSTSTSTEIT KSSPSILIPT LDGSGLLFQY SNDRLHQVPF SLQELVNTSP LFLKELEDKS STSSTSTTSE SSKDENKVTM FIGNKKTSIT VVDSQTGEII KSMSKDGLWL TDEDDCPVNI IPDEALMFTR SDYQIIALDP KSGVEKWNLS VGEYIPHSTK SFYNSEISLN FEGLIEVASL SQRMYKIYIK KPEKTVVGIS HNYWEHILTS SPVSIYAYSS KKHILKKLDF HRKVSPYSNS LIPVASTDLM IPSNFDRTFM FDDYYGQLFI VSPPSNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNK NNNNNNKNES DKSNLTPLTP YDPSKPNGAN NNNNNNNDLL DSNKLKNYDI YLYSSIVILI TSIIVFIRSK KNFNLINVNN NNNQNNNQNS NQNNNINNKK TPKKKKKKQK NKNNKNNNDE DDENEIENYN DNQNDLIDEF ISTNSVIQQQ QQQQQQLINS SNKINNGSGK IILDNGNVKI GKLEIITNKI LGTGSCGTIV YEGKMEGRKV AVKRMLSQFV KFADREVSIL IHSDEHTNVV RYYAKEEDDE FIYLAISFCQ KSLDMYVQQT LSLQISPTDS PSIQSSNNNG NGNNGNNNNN NQIIIDNKTK QMILELFKGL EHLHSLNIVH RDIKPHNVLI DPNNRVKISD MGLGKLLDND DQSLTFTSDS HGWQPAEYLN GTNRNTKKVD IFSLGCVVYY LLTGAHPFGH RYNREKNVLK GKFDIDQIKH LPDIHQLVHS MIQFEPEKRP DIGECINHPF FWEVHKKLSF LVAASDYLEF EKPTSPLNLE IDSHVDLVTD GSGDWWLKID QVLIDNIGRY RKYNGKSIRD LLRVIRNKFN HYRDLSPEEQ TCLGILPDGF FNYFDLKFPQ LFIVTYLFIL KNLKNDQYFV QYYY