INLR1_HUMAN » Interferon lambda receptor 1

INLR1_HUMAN » Interferon lambda receptor 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
INLR1_HUMAN » Interferon lambda receptor 1 » IFN-lambda receptor 1; IFN-lambda-R1; Cytokine receptor class-II member 12;Cytokine receptor family 2 member 12;CRF2-12; Interleukin-28 receptor subunit alpha;IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2;L
Hydrophobic Thickness 34.8 ± 4.8 Å
Tilt Angle 18 ± 10°
ΔGtransfer -27.2 kcal/mol
ΔGfold -18.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 227-252 (223-253)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Jak-STAT signaling pathway (KEGG)

PDB 3og4 (B=19-226), 3og6 (B=19-226)
OPM none
Complexes none
Interactions none
Domains

AA: 8-111, PDBID: 3OG4, Subunit B, Seq Identity:100%, Tissue factor

UniProt annotation for INLR1_HUMAN » Interferon lambda receptor 1
FUNCTION: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

SUBUNIT: Heterodimer with IL10RB.

TISSUE SPECIFICITY: Widely expressed.

UniProt features for INLR1_HUMAN » Interferon lambda receptor 1
SIGNAL 1 20 Potential.
CHAIN 21 520 Interferon lambda receptor 1.
DOMAIN 23 120 Fibronectin type-III.
DISULFID 74 82
DISULFID 86 150
DISULFID 195 217
Amino Acid Sequence for INLR1_HUMAN » Interferon lambda receptor 1
MAGPERWGPL LLCLLQAAPG RPRLAPPQNV TLLSQNFSVY LTWLPGLGNP QDVTYFVAYQ SSPTRRRWRE VEECAGTKEL LCSMMCLKKQ DLYNKFKGRV RTVSPSSKSP WVESEYLDYL FEVEPAPPVL VLTQTEEILS ANATYQLPPC MPPLDLKYEV AFWKEGAGNK TLFPVTPHGQ PVQITLQPAA SEHHCLSART IYTFSVPKYS KFSKPTCFLL EVPEANWAFL VLPSLLILLL VIAAGGVIWK TLMGNPWFQR AKMPRALDFS GHTHPVATFQ PSRPESVNDL FLCPQKELTR GVRPTPRVRA PATQQTRWKK DLAEDEEEED EEDTEDGVSF QPYIEPPSFL GQEHQAPGHS EAGGVDSGRP RAPLVPSEGS SAWDSSDRSW ASTVDSSWDR AGSSGYLAEK GPGQGPGGDG HQESLPPPEF SKDSGFLEEL PEDNLSSWAT WGTLPPEPNL VPGGPPVSLQ TLTFCWESSP EEEEEARESE IEDSDAGSWG AESTQRTEDR GRTLGHYMAR