INGR2_HUMAN » Interferon gamma receptor 2

INGR2_HUMAN » Interferon gamma receptor 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
INGR2_HUMAN » Interferon gamma receptor 2 » IFN-gamma receptor 2; IFN-gamma-R2; Interferon gamma receptor accessory factor 1;AF-1; Interferon gamma transducer 1;
Hydrophobic Thickness 37.2 ± 3.8 Å
Tilt Angle 4 ± 2°
ΔGtransfer -37.9 kcal/mol
ΔGfold -17.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 245-273 (244-274)
Pathways

Chagas disease (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Herpes simplex infection (KEGG)

HIF-1 signaling pathway (KEGG)

Immune System (Reactome)

Influenza A (KEGG)

Jak-STAT signaling pathway (KEGG)

Leishmaniasis (KEGG)

Measles (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

Osteoclast differentiation (KEGG)

Salmonella infection (KEGG)

Toxoplasmosis (KEGG)

Tuberculosis (KEGG)

PDB none
OPM none
Complexes none
Interactions

INGR1, Complex: INGR2:INGR1, PubMed

Domains

AA: 4-126, PDBID: 4DOH, Subunit E, Seq Identity:26%, Tissue factor

AA: 138-238, PDBID: 3WCY, Subunit A, Seq Identity:30%, Interferon-alpha/beta receptor, fibronectin type III

UniProt annotation for INGR2_HUMAN » Interferon gamma receptor 2
FUNCTION: Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2.

DISEASE: Immunodeficiency 28 (IMD28) OMIM: A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD28 manifests early in life, with severe, often fatal, infection. caused by mutations affecting the gene represented in this entry.

UniProt features for INGR2_HUMAN » Interferon gamma receptor 2
SIGNAL 1 27 Potential.
CHAIN 28 337 Interferon gamma receptor 2.
DOMAIN 31 129 Fibronectin type-III 1.
DOMAIN 139 229 Fibronectin type-III 2.
Amino Acid Sequence for INGR2_HUMAN » Interferon gamma receptor 2
MRPTLLWSLL LLLGVFAAAA AAPPDPLSQL PAPQHPKIRL YNAEQVLSWE PVALSNSTRP VVYQVQFKYT DSKWFTADIM SIGVNCTQIT ATECDFTAAS PSAGFPMDFN VTLRLRAELG ALHSAWVTMP WFQHYRNVTV GPPENIEVTP GEGSLIIRFS SPFDIADTST AFFCYYVHYW EKGGIQQVKG PFRSNSISLD NLKPSRVYCL QVQAQLLWNK SNIFRVGHLS NISCYETMAD ASTELQQVIL ISVGTFSLLS VLAGACFFLV LKYRGLIKYW FHTPPSIPLQ IEEYLKDPTQ PILEALDKDS SPKDDVWDSV SIISFPEKEQ EDVLQTL