INAR2_HUMAN » Interferon alpha/beta receptor 2

INAR2_HUMAN » Interferon alpha/beta receptor 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
INAR2_HUMAN » Interferon alpha/beta receptor 2 » IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2; Interferon alpha binding protein;Type I interferon receptor 2;
Hydrophobic Thickness 34.8 ± 4.4 Å
Tilt Angle 36 ± 3°
ΔGtransfer -26.4 kcal/mol
ΔGfold -21.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-272 (238-273)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Hepatitis C (KEGG)

Herpes simplex infection (KEGG)

Immune System (Reactome)

Influenza A (KEGG)

Jak-STAT signaling pathway (KEGG)

Measles (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

Osteoclast differentiation (KEGG)

PI3K-Akt signaling pathway (KEGG)

Toll-like receptor signaling pathway (KEGG)

PDB 3s8w (131-232), 1n6u (28-237), 1n6v (28-237), 2hym (A=28-237), 3s9d (B/D=37-232), 2kz1 (B=28-237), 2lag (B=28-237), 3se3 (C=34-232), 3se4 (C=34-232)
OPM none
Complexes

IFNA2:INAR2:INAR1_HUMAN

IFNW1:INAR2:INAR1_HUMAN

Interactions

INAR1, Complex: INAR1:INAR2, PubMed

INAR1, Complex: IFNA2:INAR2:INAR1, PDBID: 3SE3

PHAG1, Complex: PHAG1:INAR2, PubMed

Domains

AA: 8-121, PDBID: 1N6U, Subunit A, Seq Identity:100%, Tissue factor

AA: 132-231, PDBID: 1N6U, Subunit A, Seq Identity:100%, Interferon-alpha/beta receptor, fibronectin type III

UniProt annotation for INAR2_HUMAN » Interferon alpha/beta receptor 2
FUNCTION: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.

SUBUNIT: Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1.

TISSUE SPECIFICITY: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.

UniProt features for INAR2_HUMAN » Interferon alpha/beta receptor 2
SIGNAL 1 26
CHAIN 27 515 Interferon alpha/beta receptor 2.
DISULFID 39 122
DISULFID 85 93
DISULFID 207 227
Amino Acid Sequence for INAR2_HUMAN » Interferon alpha/beta receptor 2
MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA SATSTESQLI DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS PLQDPFPEED YSSTEGSGGR ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS SHLEEMVDPE DPDNVQSNHL LASGEGTQPT FPSPSSEGLW SEDAPSDQSD TSESDVDLGD GYIMR