![]() | extracellular side |
cytoplasmic side |
INAR2_HUMAN » Interferon alpha/beta receptor 2 » IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2; Interferon alpha binding protein;Type I interferon receptor 2; | |
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Hydrophobic Thickness | 37.6 ± 3.8 Å |
Tilt Angle | 0 ± 0° |
ΔGtransfer | -39.6 kcal/mol |
ΔGfold | -21.8 kcal/mol |
Links | UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC |
Topology | Out |
TM Segments | 244-272 (238-273) |
Pathways | Cytokine-cytokine receptor interaction (KEGG) Hepatitis C (KEGG) Herpes simplex infection (KEGG) Immune System (Reactome) Influenza A (KEGG) Jak-STAT signaling pathway (KEGG) Measles (KEGG) Natural killer cell mediated cytotoxicity (KEGG) Osteoclast differentiation (KEGG) PI3K-Akt signaling pathway (KEGG) |
PDB | 3s8w (131-232), 1n6u (28-237), 1n6v (28-237), 2hym (A=28-237), 3s9d (B/D=37-232), 2kz1 (B=28-237), 2lag (B=28-237), 3se3 (C=34-232), 3se4 (C=34-232) |
OPM | none |
Complexes | |
Interactions | INAR1, Complex: INAR1:INAR2, PubMed |
Domains | AA: 8-121, PDBID: 1N6U, Subunit A, Seq Identity:100%, Tissue factor AA: 132-231, PDBID: 1N6U, Subunit A, Seq Identity:100%, Interferon-alpha/beta receptor, fibronectin type III |
UniProt annotation for INAR2_HUMAN » Interferon alpha/beta receptor 2 |
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FUNCTION: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. SUBUNIT: Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1. TISSUE SPECIFICITY: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. |
UniProt features for INAR2_HUMAN » Interferon alpha/beta receptor 2 |
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SIGNAL 1 26 CHAIN 27 515 Interferon alpha/beta receptor 2. DISULFID 39 122 DISULFID 85 93 DISULFID 207 227 |
Amino Acid Sequence for INAR2_HUMAN » Interferon alpha/beta receptor 2 |
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MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA SATSTESQLI DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS PLQDPFPEED YSSTEGSGGR ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS SHLEEMVDPE DPDNVQSNHL LASGEGTQPT FPSPSSEGLW SEDAPSDQSD TSESDVDLGD GYIMR |