INAR1_HUMAN » Interferon alpha/beta receptor 1

INAR1_HUMAN » Interferon alpha/beta receptor 1
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Topology in Plasma membrane
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cytoplasmic side
INAR1_HUMAN » Interferon alpha/beta receptor 1 » IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;CRF2-1; Type I interferon receptor 1;
Hydrophobic Thickness 29.2 ± 2.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -34.2 kcal/mol
ΔGfold -17.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 434-461 (433-464)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Hepatitis B (KEGG)

Hepatitis C (KEGG)

Herpes simplex infection (KEGG)

Immune System (Reactome)

Influenza A (KEGG)

Jak-STAT signaling pathway (KEGG)

Measles (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

Osteoclast differentiation (KEGG)

PI3K-Akt signaling pathway (KEGG)

Toll-like receptor signaling pathway (KEGG)

PDB 3s98 (30-332), 3se3 (A=28-436), 3se4 (A=28-436), 4po6 (B=478-507)
OPM none
Complexes

IFNA2:INAR2:INAR1_HUMAN

IFNW1:INAR2:INAR1_HUMAN

Interactions

INAR2, Complex: INAR1:INAR2, PubMed

INAR2, Complex: IFNA2:INAR2:INAR1, PDBID: 3SE3

PTPRC, Complex: PTPRC:INAR1, PubMed

Domains

AA: 5-115, PDBID: 3S98, Subunit A, Seq Identity:100%, Tissue factor

AA: 126-224, PDBID: 3S98, Subunit A, Seq Identity:100%, Interferon-alpha/beta receptor, fibronectin type III

AA: 330-430, PDBID: 3WCY, Subunit A, Seq Identity:44%, Interferon-alpha/beta receptor, fibronectin type III

UniProt annotation for INAR1_HUMAN » Interferon alpha/beta receptor 1
FUNCTION: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

SUBUNIT: Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2.

TISSUE SPECIFICITY: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.

UniProt features for INAR1_HUMAN » Interferon alpha/beta receptor 1
SIGNAL 1 27 Potential.
CHAIN 28 557 Interferon alpha/beta receptor 1.
DOMAIN 134 224 Fibronectin type-III 1.
DOMAIN 230 326 Fibronectin type-III 2.
DOMAIN 334 425 Fibronectin type-III 3.
DISULFID 79 87
DISULFID 199 220
DISULFID 283 291
Amino Acid Sequence for INAR1_HUMAN » Interferon alpha/beta receptor 1
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT VYCVKARAHT MDEKLNKSSV FSDAVCEKTK PGNTSKIWLI VGICIALFAL PFVIYAAKVF LRCINYVFFP SLKPSSSIDE YFSEQPLKNL LLSTSEEQIE KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN EDESESKTSE ELQQDFV