IMK3_ARATH » Probable leucine-rich repeat receptor-like protein kinase IMK3

IMK3_ARATH » Probable leucine-rich repeat receptor-like protein kinase IMK3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IMK3_ARATH » Probable leucine-rich repeat receptor-like protein kinase IMK3 » Protein INFLORESCENCE MERISTEM RECEPTOR-LIKE KINASE 3;Protein MERISTEMATIC RECEPTOR-LIKE KINASE;
Hydrophobic Thickness 35.6 ± 4.0 Å
Tilt Angle 0 ± 11°
ΔGtransfer -27.7 kcal/mol
ΔGfold -23.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 409-433 (407-443)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 57-99, PDBID: 4M7E, Subunit D, Seq Identity:31%, Leucine rich repeat N-terminal domain

AA: 174-233, PDBID: 4MN8, Subunit A, Seq Identity:44%, Leucine rich repeat

AA: 246-306, PDBID: 3RGX, Subunit A, Seq Identity:40%, Leucine rich repeat

AA: 488-756, PDBID: 2NRU, Subunit B, Seq Identity:40%, Protein tyrosine kinase

UniProt annotation for IMK3_ARATH » Probable leucine-rich repeat receptor-like protein kinase IMK3
FUNCTION: Can phosphorylate AGL24.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBUNIT: Interacts with AGL24.

TISSUE SPECIFICITY: Expressed in meristems, including roots, vegetative, inflorescence and floral meristems, and in embryos.

DOMAIN: The protein kinase domain is predicted to be catalytically inactive. Lacks the conserved Asp active site at position 612, which is replaced by an Asn residue. However, according to Ref.9, the kinase activity is conserved.

UniProt features for IMK3_ARATH » Probable leucine-rich repeat receptor-like protein kinase IMK3
SIGNAL 1 48 Potential.
CHAIN 49 784 Probable leucine-rich repeat receptor- like protein kinase IMK3.
REPEAT 126 148 LRR 1.
REPEAT 150 172 LRR 2.
REPEAT 174 197 LRR 3.
REPEAT 198 220 LRR 4.
REPEAT 222 242 LRR 5.
REPEAT 247 268 LRR 6.
REPEAT 271 294 LRR 7.
REPEAT 295 317 LRR 8.
REPEAT 319 342 LRR 9.
REPEAT 343 365 LRR 10.
DOMAIN 488 773 Protein kinase.
Amino Acid Sequence for IMK3_ARATH » Probable leucine-rich repeat receptor-like protein kinase IMK3
MEFITQNQAI TSLSMINTDI DQPKASLRSR FLLHLIICLL FFVPPCSSQA WDGVVITQAD YQGLQAVKQE LIDPRGFLRS WNGSGFSACS GGWAGIKCAQ GQVIVIQLPW KSLGGRISEK IGQLQALRKL SLHDNNLGGS IPMSLGLIPN LRGVQLFNNR LTGSIPASLG VSHFLQTLDL SNNLLSEIIP PNLADSSKLL RLNLSFNSLS GQIPVSLSRS SSLQFLALDH NNLSGPILDT WGSKSLNLRV LSLDHNSLSG PFPFSLCNLT QLQDFSFSHN RIRGTLPSEL SKLTKLRKMD ISGNSVSGHI PETLGNISSL IHLDLSQNKL TGEIPISISD LESLNFFNVS YNNLSGPVPT LLSQKFNSSS FVGNSLLCGY SVSTPCPTLP SPSPEKERKP SHRNLSTKDI ILIASGALLI VMLILVCVLC CLLRKKANET KAKGGEAGPG AVAAKTEKGG EAEAGGETGG KLVHFDGPMA FTADDLLCAT AEIMGKSTYG TVYKATLEDG SQVAVKRLRE KITKSQKEFE NEINVLGRIR HPNLLALRAY YLGPKGEKLV VFDYMSRGSL ATFLHARGPD VHINWPTRMS LIKGMARGLF YLHTHANIIH GNLTSSNVLL DENITAKISD YGLSRLMTAA AGSSVIATAG ALGYRAPELS KLKKANTKTD VYSLGVIILE LLTGKSPSEA LNGVDLPQWV ATAVKEEWTN EVFDLELLND VNTMGDEILN TLKLALHCVD ATPSTRPEAQ QVMTQLGEIR PEETTATTSE PLIDVPEASA STSQ