ILRL2_HUMAN » Interleukin-1 receptor-like 2

ILRL2_HUMAN » Interleukin-1 receptor-like 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ILRL2_HUMAN » Interleukin-1 receptor-like 2 » Interleukin-1 receptor-related protein 2;IL-1Rrp2; IL1R-rp2;
Hydrophobic Thickness 32.0 ± 2.2 Å
Tilt Angle 3 ± 0°
ΔGtransfer -40.2 kcal/mol
ΔGfold -16.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 332-359 (332-359)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 25-112, PDBID: 1E4J, Subunit A, Seq Identity:25%, Immunoglobulin domain

AA: 125-214, PDBID: 1G0Y, Subunit R, Seq Identity:27%, Immunoglobulin domain

AA: 385-575, PDBID: 1T3G, Subunit B, Seq Identity:25%, TIR domain

UniProt annotation for ILRL2_HUMAN » Interleukin-1 receptor-like 2
FUNCTION: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway.

SUBUNIT: Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN (By similarity).

TISSUE SPECIFICITY: Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte- derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.

UniProt features for ILRL2_HUMAN » Interleukin-1 receptor-like 2
SIGNAL 1 19 Potential.
CHAIN 20 575 Interleukin-1 receptor-like 2.
DOMAIN 20 111 Ig-like C2-type 1.
DOMAIN 126 211 Ig-like C2-type 2.
DOMAIN 222 318 Ig-like C2-type 3.
DOMAIN 381 539 TIR.
DISULFID 42 95 By similarity.
DISULFID 146 195 By similarity.
DISULFID 249 316 By similarity.
Amino Acid Sequence for ILRL2_HUMAN » Interleukin-1 receptor-like 2
MWSLLLCGLS IALPLSVTAD GCKDIFMKNE ILSASQPFAF NCTFPPITSG EVSVTWYKNS SKIPVSKIIQ SRIHQDETWI LFLPMEWGDS GVYQCVIKGR DSCHRIHVNL TVFEKHWCDT SIGGLPNLSD EYKQILHLGK DDSLTCHLHF PKSCVLGPIK WYKDCNEIKG ERFTVLETRL LVSNVSAEDR GNYACQAILT HSGKQYEVLN GITVSITERA GYGGSVPKII YPKNHSIEVQ LGTTLIVDCN VTDTKDNTNL RCWRVNNTLV DDYYDESKRI REGVETHVSF REHNLYTVNI TFLEVKMEDY GLPFMCHAGV STAYIILQLP APDFRAYLIG GLIALVAVAV SVVYIYNIFK IDIVLWYRSA FHSTETIVDG KLYDAYVLYP KPHKESQRHA VDALVLNILP EVLERQCGYK LFIFGRDEFP GQAVANVIDE NVKLCRRLIV IVVPESLGFG LLKNLSEEQI AVYSALIQDG MKVILIELEK IEDYTVMPES IQYIKQKHGA IRWHGDFTEQ SQCMKTKFWK TVRYHMPPRR CRPFPPVQLL QHTPCYRTAG PELGSRRKKC TLTTG