ILRL1_HUMAN » Interleukin-1 receptor-like 1

ILRL1_HUMAN » Interleukin-1 receptor-like 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ILRL1_HUMAN » Interleukin-1 receptor-like 1 » Protein ST2;
Hydrophobic Thickness 35.2 ± 2.2 Å
Tilt Angle 25 ± 6°
ΔGtransfer -26.3 kcal/mol
ΔGfold -19.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 331-356 (326-357)
Pathways none
PDB 4kc3 (B=19-321)
OPM none
Complexes none
Interactions

A4, Complex: A4:ILRL1, PubMed

CLC7A, Complex: ILRL1:CLC7A

TMED1, Complex: ILRL1:TMED1, PubMed

Domains

AA: 18-104, PDBID: 4KC3, Subunit B, Seq Identity:100%, Immunoglobulin I-set domain

AA: 379-555, PDBID: 1T3G, Subunit B, Seq Identity:27%, TIR domain

UniProt annotation for ILRL1_HUMAN » Interleukin-1 receptor-like 1
FUNCTION: Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

SUBUNIT: Interacts with MYD88, IRAK1, IRAK4, and TRAF6.

TISSUE SPECIFICITY: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.

UniProt features for ILRL1_HUMAN » Interleukin-1 receptor-like 1
SIGNAL 1 18
CHAIN 19 556 Interleukin-1 receptor-like 1.
DOMAIN 19 103 Ig-like C2-type 1.
DOMAIN 114 197 Ig-like C2-type 2.
DOMAIN 212 319 Ig-like C2-type 3.
DOMAIN 375 538 TIR.
DISULFID 36 87 By similarity.
DISULFID 133 181 By similarity.
DISULFID 235 303 By similarity.
Amino Acid Sequence for ILRL1_HUMAN » Interleukin-1 receptor-like 1
MGFWILAILT ILMYSTAAKF SKQSWGLENE ALIVRCPRQG KPSYTVDWYY SQTNKSIPTQ ERNRVFASGQ LLKFLPAAVA DSGIYTCIVR SPTFNRTGYA NVTIYKKQSD CNVPDYLMYS TVSGSEKNSK IYCPTIDLYN WTAPLEWFKN CQALQGSRYR AHKSFLVIDN VMTEDAGDYT CKFIHNENGA NYSVTATRSF TVKDEQGFSL FPVIGAPAQN EIKEVEIGKN ANLTCSACFG KGTQFLAAVL WQLNGTKITD FGEPRIQQEE GQNQSFSNGL ACLDMVLRIA DVKEEDLLLQ YDCLALNLHG LRRHTVRLSR KNPIDHHSIY CIIAVCSVFL MLINVLVIIL KMFWIEATLL WRDIAKPYKT RNDGKLYDAY VVYPRNYKSS TDGASRVEHF VHQILPDVLE NKCGYTLCIY GRDMLPGEDV VTAVETNIRK SRRHIFILTP QITHNKEFAY EQEVALHCAL IQNDAKVILI EMEALSELDM LQAEALQDSL QHLMKVQGTI KWREDHIANK RSLNSKFWKH VRYQMPVPSK IPRKASSLTP LAAQKQ