IL9R_HUMAN » Interleukin-9 receptor

IL9R_HUMAN » Interleukin-9 receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL9R_HUMAN » Interleukin-9 receptor » IL-9 receptor; IL-9R;
Hydrophobic Thickness 30.0 ± 2.4 Å
Tilt Angle 8 ± 7°
ΔGtransfer -20.9 kcal/mol
ΔGfold -11.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 273-293 (272-294)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

Jak-STAT signaling pathway (KEGG)

PDB none
OPM none
Complexes none
Interactions

IL2RG, Complex: IL9R:IL2RG, PubMed

Domains none
UniProt annotation for IL9R_HUMAN » Interleukin-9 receptor
FUNCTION: This is a receptor for interleukin-9.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.

UniProt features for IL9R_HUMAN » Interleukin-9 receptor
SIGNAL 1 40 Potential.
CHAIN 41 521 Interleukin-9 receptor.
DOMAIN 150 244 Fibronectin type-III.
MOTIF 245 249 WSXWS motif.
MOTIF 301 309 Box 1 motif.
Amino Acid Sequence for IL9R_HUMAN » Interleukin-9 receptor
MGLGRCIWEG WTLESEALRR DMGTWLLACI CICTCVCLGV SVTGEGQGPR SRTFTCLTNN ILRIDCHWSA PELGQGSSPW LLFTSNQAPG GTHKCILRGS ECTVVLPPEA VLVPSDNFTI TFHHCMSGRE QVSLVDPEYL PRRHVKLDPP SDLQSNISSG HCILTWSISP ALEPMTTLLS YELAFKKQEE AWEQAQHRDH IVGVTWLILE AFELDPGFIH EARLRVQMAT LEDDVVEEER YTGQWSEWSQ PVCFQAPQRQ GPLIPPWGWP GNTLVAVSIF LLLTGPTYLL FKLSPRVKRI FYQNVPSPAM FFQPLYSVHN GNFQTWMGAH GAGVLLSQDC AGTPQGALEP CVQEATALLT CGPARPWKSV ALEEEQEGPG TRLPGNLSSE DVLPAGCTEW RVQTLAYLPQ EDWAPTSLTR PAPPDSEGSR SSSSSSSSNN NNYCALGCYG GWHLSALPGN TQSSGPIPAL ACGLSCDHQG LETQQGVAWV LAGHCQRPGL HEDLQGMLLP SVLSKARSWT F