IL7RA_HUMAN » Interleukin-7 receptor subunit alpha

IL7RA_HUMAN » Interleukin-7 receptor subunit alpha
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL7RA_HUMAN » Interleukin-7 receptor subunit alpha » IL-7R-alpha; CDw127;
Hydrophobic Thickness 32.8 ± 1.4 Å
Tilt Angle 2 ± 2°
ΔGtransfer -41.9 kcal/mol
ΔGfold -24.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 240-265 (240-268)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

Jak-STAT signaling pathway (KEGG)

PI3K-Akt signaling pathway (KEGG)

Primary immunodeficiency (KEGG)

PDB 3up1 (A/B=21-239), 3di2 (B/D=21-239), 3di3 (B=21-239)
OPM none
Complexes

IL7RA:CRLF2:TSLP_MOUSE

IL7RA:IL7RA_HUMAN

Interactions

CLIC1, Complex: CLIC1:IL7RA, PubMed

CRLF2, Complex: IL7RA:CRLF2:TSLP, PDBID: 4nn5, PubMed

IL2RG, Complex: IL2RG:IL7RA, PubMed

IL7RA, Complex: Homodimer of interleukin-7 receptor subunit alpha, PDBID: 3UP1

ITA2B, Complex: ITA2B:IL7RA, PubMed

KIT, Complex: KIT:IL7RA, PubMed

Domains

AA: 130-218, PDBID: 3DI2, Subunit D, Seq Identity:100%, Fibronectin type III domain

UniProt annotation for IL7RA_HUMAN » Interleukin-7 receptor subunit alpha
FUNCTION: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

SUBUNIT: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

DISEASE: Severe combined immunodeficiency autosomal recessive T- cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) OMIM: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Note=The disease is caused by mutations affecting the gene represented in this entry.

DISEASE: Multiple sclerosis 3 (MS3) OMIM: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major "C" allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either "C" allele (Thr-244) or "T" allele (Ile-244) shows that the "C" allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated "C" risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS.

UniProt features for IL7RA_HUMAN » Interleukin-7 receptor subunit alpha
SIGNAL 1 20
CHAIN 21 459 Interleukin-7 receptor subunit alpha.
DOMAIN 128 224 Fibronectin type-III.
MOTIF 217 221 WSXWS motif.
MOTIF 272 280 Box 1 motif.
DISULFID 42 57
DISULFID 74 82
DISULFID 108 118
Amino Acid Sequence for IL7RA_HUMAN » Interleukin-7 receptor subunit alpha
MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE DPDVNTTNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL LIGKSNICVK VGEKSLTCKK IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWTH VNLSSTKLTL LQRKLQPAAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGEMDP ILLTISILSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP SEDVVITPES FGRDSSLTCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ