IL6RB_HUMAN » Interleukin-6 receptor subunit beta

IL6RB_HUMAN » Interleukin-6 receptor subunit beta
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Topology in Plasma membrane
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IL6RB_HUMAN » Interleukin-6 receptor subunit beta » IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; CDw130;Interleukin-6 signal transducer;Membrane glycoprotein 130;gp130; Oncostatin-M receptor subunit alpha;
Hydrophobic Thickness 34.4 ± 1.6 Å
Tilt Angle 1 ± 1°
ΔGtransfer -37.7 kcal/mol
ΔGfold -16.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 617-642 (617-644)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Immune System (Reactome)

Jak-STAT signaling pathway (KEGG)

Viral carcinogenesis (KEGG)

PDB 1bj8 (219-325), 3l5h (24-612), 3l5j (323-610), 3l5i (323-612), 1bqu (A/B=122-333), 1pvh (A/C=123-323), 1p9m (A=23-321), 1i1r (A=23-325)
OPM none
Complexes

IL6RA:IL6RB:IL6_HUMAN

IL6RB:IL6RB_HUMAN

Interactions

ERBB2, Complex: IL6RB:ERBB2, PubMed

ERBB3, Complex: IL6RB:ERBB3, PubMed

I11RA, Complex: IL11:I11RA:IL6RB, PubMed

IL31R, Complex: IL31R:IL6RB, PubMed

IL6RA, Complex: IL6RA:IL6RB:IL6, PDBID: 1p9m, PubMed

IL6RA, Complex: IL6RA:IL6RB, PDBID: 1n2q, PubMed

IL6RB, Complex: Homodimer of interleukin-6 receptor subunit beta, PDBID: 1BQU

LIFR, Complex: IL6RB:LIFR:LIF, PubMed

OSMR, Complex: IL6RB:OSMR, PubMed

Domains

AA: 26-112, PDBID: 1I1R, Subunit A, Seq Identity:100%, Ig-like C2-type domain

AA: 131-218, PDBID: 1BQU, Subunit B, Seq Identity:100%, Interleukin-6 receptor alpha chain, binding

AA: 223-311, PDBID: 1BJ8, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 518-605, PDBID: 3L5H, Subunit A, Seq Identity:100%, Fibronectin type III domain

UniProt annotation for IL6RB_HUMAN » Interleukin-6 receptor subunit beta
FUNCTION: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.

SUBUNIT: Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK.

TISSUE SPECIFICITY: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.

INDUCTION: LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

UniProt features for IL6RB_HUMAN » Interleukin-6 receptor subunit beta
SIGNAL 1 22
CHAIN 23 918 Interleukin-6 receptor subunit beta.
DOMAIN 26 120 Ig-like C2-type.
DOMAIN 125 216 Fibronectin type-III 1.
DOMAIN 222 321 Fibronectin type-III 2.
DOMAIN 326 418 Fibronectin type-III 3.
DOMAIN 423 514 Fibronectin type-III 4.
DOMAIN 518 610 Fibronectin type-III 5.
MOTIF 310 314 WSXWS motif.
MOTIF 651 659 Box 1 motif.
DISULFID 28 54
DISULFID 48 103
DISULFID 134 144
DISULFID 172 182
DISULFID 458 466
Amino Acid Sequence for IL6RB_HUMAN » Interleukin-6 receptor subunit beta
MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL KEKCMDYFHV NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ LTCNILTFGQ LEQNVYGITI ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR ETHLETNFTL KSEWATHKFA DCKAKRDTPT SCTVDYSTVY FVNIEVWVEA ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL KLTWTNPSIK SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV WKTLPPFEAN GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL TVRNLVGKSD AAVLTIPACD FQATHPVMDL KAFPKDNMLW VEWTTPRESV KKYILEWCVL SDKAPCITDW QQEDGTVHRT YLRGNLAESK CYLITVTPVY ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD QLPVDVQNGF IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH IWPNVPDPSK SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND KKPFPEDLKS LDLFKKEKIN TEGHSSGIGG SSCMSSSRPS ISSSDENESS QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS ESTQPLLDSE ERPEDLQLVD HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV NEEDFVRLKQ QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG MPKSYLPQTV RQGGYMPQ