IL6RA_HUMAN » Interleukin-6 receptor subunit alpha

IL6RA_HUMAN » Interleukin-6 receptor subunit alpha
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Topology in Plasma membrane
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IL6RA_HUMAN » Interleukin-6 receptor subunit alpha » IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1;Membrane glycoprotein 80;gp80;
Hydrophobic Thickness 33.6 ± 1.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -41.2 kcal/mol
ΔGfold -13.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 364-389 (363-390)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

HIF-1 signaling pathway (KEGG)

Immune System (Reactome)

Jak-STAT signaling pathway (KEGG)

PI3K-Akt signaling pathway (KEGG)

PDB 2arw (212-336), 1n26 (A=20-344), 1p9m (C=115-315)
OPM none
Complexes

IL6RA:IL6RB:IL6_HUMAN

Interactions

ADA17, Complex: IL6RA:ADA17, PubMed

ERAP1, Complex: ERAP1:IL6RA, PubMed

IL6RB, Complex: IL6RA:IL6RB:IL6, PDBID: 1p9m, PubMed

IL6RB, Complex: IL6RA:IL6RB, PDBID: 1n2q, PubMed

Domains

AA: 30-101, PDBID: 1N26, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 118-213, PDBID: 1N26, Subunit A, Seq Identity:100%, Interleukin-6 receptor alpha chain, binding

UniProt annotation for IL6RA_HUMAN » Interleukin-6 receptor subunit alpha
FUNCTION: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

FUNCTION: Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

SUBUNIT: Hexamer of two molecules each of IL6, IL6R and IL6ST.

TISSUE SPECIFICITY: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

DOMAIN: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

UniProt features for IL6RA_HUMAN » Interleukin-6 receptor subunit alpha
SIGNAL 1 19
CHAIN 20 468 Interleukin-6 receptor subunit alpha.
DOMAIN 26 112 Ig-like C2-type.
DOMAIN 216 311 Fibronectin type-III.
MOTIF 303 307 WSXWS motif.
SITE 245 245 Not glycosylated.
DISULFID 25 193
DISULFID 47 96
DISULFID 121 132
DISULFID 165 176
Amino Acid Sequence for IL6RA_HUMAN » Interleukin-6 receptor subunit alpha
MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPVQDSS SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG KTSMHPPYSL GQLVPERPRP TPVLVPLISP PVSPSSLGSD NTSSHNRPDA RDPRSPYDIS NTDYFFPR