IL5RA_HUMAN » Interleukin-5 receptor subunit alpha

IL5RA_HUMAN » Interleukin-5 receptor subunit alpha
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL5RA_HUMAN » Interleukin-5 receptor subunit alpha » IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA; CDw125;
Hydrophobic Thickness 34.8 ± 4.8 Å
Tilt Angle 44 ± 0°
ΔGtransfer -32.3 kcal/mol
ΔGfold -22.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 340-369 (340-372)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

Jak-STAT signaling pathway (KEGG)

PDB 3qt2 (A/B=20-335), 1obx (B=413-420), 3va2 (C=21-335), 1obz (P=413-420)
OPM none
Complexes none
Interactions

IL3RB, Complex: IL5RA:IL3RB:IL5, PubMed

Domains

AA: 131-236, PDBID: 3QT2, Subunit B, Seq Identity:100%, Interleukin-6 receptor alpha chain, binding

UniProt annotation for IL5RA_HUMAN » Interleukin-5 receptor subunit alpha
FUNCTION: This is the receptor for interleukin-5. The alpha chain binds to IL5.

SUBUNIT: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.

TISSUE SPECIFICITY: Expressed on eosinophils and basophils.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

UniProt features for IL5RA_HUMAN » Interleukin-5 receptor subunit alpha
SIGNAL 1 20
CHAIN 21 420 Interleukin-5 receptor subunit alpha.
MOTIF 322 326 WSXWS motif.
MOTIF 371 379 Box 1 motif.
Amino Acid Sequence for IL5RA_HUMAN » Interleukin-5 receptor subunit alpha
MIIVAHVLLI LLGATEILQA DLLPDEKISL LPPVNFTIKV TGLAQVLLQW KPNPDQEQRN VNLEYQVKIN APKEDDYETR ITESKCVTIL HKGFSASVRT ILQNDHSLLA SSWASAELHA PPGSPGTSIV NLTCTTNTTE DNYSRLRSYQ VSLHCTWLVG TDAPEDTQYF LYYRYGSWTE ECQEYSKDTL GRNIACWFPR TFILSKGRDW LAVLVNGSSK HSAIRPFDQL FALHAIDQIN PPLNVTAEIE GTRLSIQWEK PVSAFPIHCF DYEVKIHNTR NGYLQIEKLM TNAFISIIDD LSKYDVQVRA AVSSMCREAG LWSEWSQPIY VGNDEHKPLR EWFVIVIMAT ICFILLILSL ICKICHLWIK LFPPIPAPKS NIKDLFVTTN YEKAGSSETE IEVICYIEKP GVETLEDSVF