IL4RA_HUMAN » Interleukin-4 receptor subunit alpha

IL4RA_HUMAN » Interleukin-4 receptor subunit alpha
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL4RA_HUMAN » Interleukin-4 receptor subunit alpha » IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA;
Hydrophobic Thickness 39.6 ± 5.0 Å
Tilt Angle 0 ± 3°
ΔGtransfer -33.1 kcal/mol
ΔGfold -15.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 231-257 (228-260)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

Jak-STAT signaling pathway (KEGG)

PI3K-Akt signaling pathway (KEGG)

PDB 1iar (B=26-232), 3bpl (B=27-227), 3bpn (B=27-227), 3bpo (B=27-227), 1irs (B=489-499)
OPM none
Complexes

IL4RA:I13R1:IL13_HUMAN

IL4RA:I13R1:IL4_HUMAN

IL4RA:IL2RG:IL4_HUMAN

Interactions

I13R1, Complex: I13R1:IL13:IL4RA, PDBID: 3bpo

IL2RG, Complex: IL2RG:IL4RA:IL4, PDBID: 1ite

TNR5, Complex: IL4RA:TNR5, PubMed

Domains

AA: 28-121, PDBID: 1IAR, Subunit B, Seq Identity:100%, Interleukin-4 receptor alpha chain, N-terminal

UniProt annotation for IL4RA_HUMAN » Interleukin-4 receptor subunit alpha
FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

SUBUNIT: The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling (By similarity).

TISSUE SPECIFICITY: Isoform 1 and isoform 2 are highly expressed in activated T-cells.

DOMAIN: The extracellular domain represents the IL4 binding protein (IL4BP).

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for IL4RA_HUMAN » Interleukin-4 receptor subunit alpha
SIGNAL 1 25 By similarity.
CHAIN 26 825 Interleukin-4 receptor subunit alpha.
CHAIN 26 ? Soluble interleukin-4 receptor subunit alpha.
DOMAIN 123 219 Fibronectin type-III.
REGION 437 557 Required for IRS1 activation and IL4- induced cell growth.
REGION 558 657 Required for IL4-induced gene expression.
MOTIF 212 216 WSXWS motif.
MOTIF 262 270 Box 1 motif.
MOTIF 711 716 ITIM motif.
SITE 38 38 Major IL4 binding determinant.
SITE 64 64 Minor IL4 binding determinant.
SITE 66 66 Minor IL4 binding determinant.
SITE 92 92 Minor IL4 binding determinant.
SITE 94 94 Minor IL4 binding determinant.
SITE 97 97 Major IL4 binding determinant.
SITE 152 152 Minor IL4 binding determinant.
SITE 208 208 Major IL4 binding determinant.
DISULFID 34 44 By similarity.
DISULFID 74 86 By similarity.
Amino Acid Sequence for IL4RA_HUMAN » Interleukin-4 receptor subunit alpha
MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG PTNCSTELRL LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT LDLWAGQQLL WKGSFKPSEH VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD NYLYNHLTYA VNIWSENDPA DFRIYNVTYL EPSLRIAAST LKSGISYRAR VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS CIVILAVCLL CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV LWPESISVVR CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE GIVARLTESL FLDLLGEENG GFCQQDMGES CLLPPSGSTS AHMPWDEFPS AGPKEAPPWG KEQPLHLEPS PPASPTQSPD NLTCTETPLV IAGNPAYRSF SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT TVPQPEPETW EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV PLFTFGLDRE PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT DPLVDSLGSG IVYSALTCHL CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD RSSPPTTPLR APDPSPGGVP LEASLCPASL APSGISEKSK SSSSFHPAPG NAQSSSQTPK IVNFVSVGPT YMRVS