IL3RA_HUMAN » Interleukin-3 receptor subunit alpha

IL3RA_HUMAN » Interleukin-3 receptor subunit alpha
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL3RA_HUMAN » Interleukin-3 receptor subunit alpha » IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA;
Hydrophobic Thickness 35.2 ± 4.0 Å
Tilt Angle 15 ± 8°
ΔGtransfer -25.3 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 304-328 (295-332)
Pathways

Apoptosis (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

Jak-STAT signaling pathway (KEGG)

PI3K-Akt signaling pathway (KEGG)

PDB 4jzj (C/D=20-307)
OPM none
Complexes none
Interactions

EPOR, Complex: IL3RA:TEC:VAV:EPOR, PubMed

IL3RA, Complex: Homodimer of interleukin-3 receptor subunit alpha, PDBID: 4JZJ

IL3RB, Complex: IL3RB:IL3:IL3RA, PubMed

Domains

AA: 109-205, PDBID: 4JZJ, Subunit D, Seq Identity:100%, Interleukin-6 receptor alpha chain, binding

UniProt annotation for IL3RA_HUMAN » Interleukin-3 receptor subunit alpha
FUNCTION: This is a receptor for interleukin-3.

SUBUNIT: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

UniProt features for IL3RA_HUMAN » Interleukin-3 receptor subunit alpha
SIGNAL 1 18 Potential.
CHAIN 19 378 Interleukin-3 receptor subunit alpha.
MOTIF 282 286 WSXWS motif.
MOTIF 334 342 Box 1 motif.
Amino Acid Sequence for IL3RA_HUMAN » Interleukin-3 receptor subunit alpha
MVLLWLTLLL IALPCLLQTK EDPNPPITNL RMKAKAQQLT WDLNRNVTDI ECVKDADYSM PAVNNSYCQF GAISLCEVTN YTVRVANPPF STWILFPENS GKPWAGAENL TCWIHDVDFL SCSWAVGPGA PADVQYDLYL NVANRRQQYE CLHYKTDAQG TRIGCRFDDI SRLSSGSQSS HILVRGRSAA FGIPCTDKFV VFSQIEILTP PNMTAKCNKT HSFMHWKMRS HFNRKFRYEL QIQKRMQPVI TEQVRDRTSF QLLNPGTYTV QIRARERVYE FLSAWSTPQR FECDQEEGAN TRAWRTSLLI ALGTLLALVC VFVICRRYLV MQRLFPRIPH MKDPIGDSFQ NDKLVVWEAG KAGLEECLVT EVQVVQKT