IL2RG_HUMAN » Cytokine receptor common subunit gamma

IL2RG_HUMAN » Cytokine receptor common subunit gamma
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Topology in Plasma membrane
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IL2RG_HUMAN » Cytokine receptor common subunit gamma » Interleukin-2 receptor subunit gamma;IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC;p64;
Hydrophobic Thickness 37.2 ± 1.4 Å
Tilt Angle 6 ± 3°
ΔGtransfer -44.0 kcal/mol
ΔGfold -13.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 255-283 (255-287)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Endocytosis (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Jak-STAT signaling pathway (KEGG)

Measles (KEGG)

PI3K-Akt signaling pathway (KEGG)

Primary immunodeficiency (KEGG)

PDB 3qb7 (C/D=55-254), 3qaz (C/F...=56-254), 2erj (C/G=23-255), 4gs7 (C=55-254), 2b5i (C=56-254), 3bpl (C=56-254)
OPM none
Complexes

IL2:IL2RB:IL2RG_HUMAN

IL2RA:IL2:IL2RB:IL2RG_HUMAN

IL2RB:IL2RG:IL15:I15RA_HUMAN

IL4RA:IL2RG:IL4_HUMAN

Interactions

I13R1, Complex: IL2RG:I13R1, PubMed

I15RA, Complex: I15RA:IL2RG, PubMed

ICAM1, Complex: IL2RG:ICAM1, PubMed

IL2RA, Complex: IL2RA:IL2RB:IL2RG, PDBID: 1ilm

IL2RB, Complex: IL2RA:IL2RB:IL2RG, PDBID: 1ilm

IL4RA, Complex: IL2RG:IL4RA:IL4, PDBID: 1ite

IL9R, Complex: IL9R:IL2RG, PubMed

PTPRJ, Complex: IL2RG:PTPRJ, PubMed

UFO, Complex: IL2RG:UFO, PubMed

Domains

AA: 59-151, PDBID: 2B5I, Subunit C, Seq Identity:100%, Interleukin-6 receptor alpha chain, binding

UniProt annotation for IL2RG_HUMAN » Cytokine receptor common subunit gamma
FUNCTION: Common subunit for the receptors for a variety of interleukins.

SUBUNIT: The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

DISEASE: Severe combined immunodeficiency X-linked T-cell- negative/B-cell-positive/NK-cell-negative (XSCID) OMIM: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. disease is caused by mutations affecting the gene represented in this entry.

DISEASE: X-linked combined immunodeficiency (XCID) OMIM: Less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. mutations affecting the gene represented in this entry.

UniProt features for IL2RG_HUMAN » Cytokine receptor common subunit gamma
SIGNAL 1 22
CHAIN 23 369 Cytokine receptor common subunit gamma.
DOMAIN 154 241 Fibronectin type-III.
MOTIF 237 241 WSXWS motif.
MOTIF 286 294 Box 1 motif.
DISULFID 62 72
DISULFID 102 115
DISULFID 182 231
Amino Acid Sequence for IL2RG_HUMAN » Cytokine receptor common subunit gamma
MLKPSLPFTS LLFLQLPLLG VGLNTTILTP NGNEDTTADF FLTTMPTDSL SVSTLPLPEV QCFVFNVEYM NCTWNSSSEP QPTNLTLHYW YKNSDNDKVQ KCSHYLFSEE ITSGCQLQKK EIHLYQTFVV QLQDPREPRR QATQMLKLQN LVIPWAPENL TLHKLSESQL ELNWNNRFLN HCLEHLVQYR TDWDHSWTEQ SVDYRHKFSL PSVDGQKRYT FRVRSRFNPL CGSAQHWSEW SHPIHWGSNT SKENPFLFAL EAVVISVGSM GLIISLLCVY FWLERTMPRI PTLKNLEDLV TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP CNQHSPYWAP PCYTLKPET