IL2RB_HUMAN » Interleukin-2 receptor subunit beta

IL2RB_HUMAN » Interleukin-2 receptor subunit beta
Magnify IL2RB_HUMAN » Interleukin-2 receptor subunit betaEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL2RB_HUMAN » Interleukin-2 receptor subunit beta » IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta;p70-75;p75;
Hydrophobic Thickness 29.6 ± 2.2 Å
Tilt Angle 4 ± 2°
ΔGtransfer -32.2 kcal/mol
ΔGfold -14.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 240-265 (240-268)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Endocytosis (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Jak-STAT signaling pathway (KEGG)

Measles (KEGG)

PI3K-Akt signaling pathway (KEGG)

Transcriptional misregulation in cancer (KEGG)

PDB 3qaz (B/E...=24-240), 2erj (B/F=27-232), 2b5i (B=27-240), 4gs7 (B=27-240)
OPM none
Complexes

IL2:IL2RB:IL2RG_HUMAN

IL2RA:IL2:IL2RB:IL2RG_HUMAN

IL2RB:IL2RG:IL15:I15RA_HUMAN

Interactions

I15RA, Complex: I15RA:IL2RB, PubMed

IL2RA, Complex: IL2RA:IL2RB:IL2RG, PDBID: 1ilm

IL2RG, Complex: IL2RA:IL2RB:IL2RG, PDBID: 1ilm

Domains none
UniProt annotation for IL2RB_HUMAN » Interleukin-2 receptor subunit beta
FUNCTION: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

SUBUNIT: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

UniProt features for IL2RB_HUMAN » Interleukin-2 receptor subunit beta
SIGNAL 1 26
CHAIN 27 551 Interleukin-2 receptor subunit beta.
DOMAIN 131 229 Fibronectin type-III.
MOTIF 220 224 WSXWS motif.
MOTIF 278 286 Box 1 motif.
DISULFID 36 46
DISULFID 59 110
DISULFID 74 86
Amino Acid Sequence for IL2RB_HUMAN » Interleukin-2 receptor subunit beta
MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ DGALQDTSCQ VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT VDIVTLRVLC REGVRWRVMA IQDFKPFENL RLMAPISLQV VHVETHRCNI SWEISQASHY FERHLEFEAR TLSPGHTWEE APLLTLKQKQ EWICLETLTP DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT IPWLGHLLVG LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS SNHSLTSCFT NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP TGSSPQPLQP LSGEDDAYCT FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP DLVDFQPPPE LVLREAGEEV PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ ELQGQDPTHL V