IL21R_HUMAN » Interleukin-21 receptor

IL21R_HUMAN » Interleukin-21 receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL21R_HUMAN » Interleukin-21 receptor » IL-21 receptor; IL-21R; Novel interleukin receptor;
Hydrophobic Thickness 31.2 ± 2.2 Å
Tilt Angle 3 ± 2°
ΔGtransfer -23.3 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 236-256 (236-256)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Jak-STAT signaling pathway (KEGG)

PDB 4nzd (A/B/C=20-232), 3tgx (A/C...=20-232)
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for IL21R_HUMAN » Interleukin-21 receptor
FUNCTION: This is a receptor for interleukin-21.

SUBUNIT: Heterodimer with the common gamma subunit. Associates with JAK1.

TISSUE SPECIFICITY: Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

DISEASE: IL21R immunodeficiency (IL21RID) OMIM: An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens. mutations affecting the gene represented in this entry.

DISEASE: Note=Chromosomal aberrations involving IL21R is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;16)(q27;p11), with BCL6.

UniProt features for IL21R_HUMAN » Interleukin-21 receptor
SIGNAL 1 19
CHAIN 20 538 Interleukin-21 receptor.
DOMAIN 21 118 Fibronectin type-III 1.
DOMAIN 124 209 Fibronectin type-III 2.
MOTIF 214 218 WSXWS motif.
MOTIF 266 274 Box 1 motif.
DISULFID 20 109
DISULFID 25 35
DISULFID 65 81
Amino Acid Sequence for IL21R_HUMAN » Interleukin-21 receptor
MPRGWAAPLL LLLLQGGWGC PDLVCYTDYL QTVICILEMW NLHPSTLTLT WQDQYEELKD EATSCSLHRS AHNATHATYT CHMDVFHFMA DDIFSVNITD QSGNYSQECG SFLLAESIKP APPFNVTVTF SGQYNISWRS DYEDPAFYML KGKLQYELQY RNRGDPWAVS PRRKLISVDS RSVSLLPLEF RKDSSYELQV RAGPMPGSSY QGTWSEWSDP VIFQTQSEEL KEGWNPHLLL LLLLVIVFIP AFWSLKTHPL WRLWKKIWAV PSPERFFMPL YKGCSGDFKK WVGAPFTGSS LELGPWSPEV PSTLEVYSCH PPRSPAKRLQ LTELQEPAEL VESDGVPKPS FWPTAQNSGG SAYSEERDRP YGLVSIDTVT VLDAEGPCTW PCSCEDDGYP ALDLDAGLEP SPGLEDPLLD AGTTVLSCGC VSAGSPGLGG PLGSLLDRLK PPLADGEDWA GGLPWGGRSP GGVSESEAGS PLAGLDMDTF DSGFVGSDCS SPVECDFTSP GDEGPPRSYL RQWVVIPPPL SSPGPQAS