IL1R2_HUMAN » Interleukin-1 receptor type 2

IL1R2_HUMAN » Interleukin-1 receptor type 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL1R2_HUMAN » Interleukin-1 receptor type 2 » IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B;CDw121b;IL-1 type II receptor;Interleukin-1 receptor beta;IL-1R-beta; Interleukin-1 receptor type II;
Hydrophobic Thickness 35.2 ± 2.2 Å
Tilt Angle 6 ± 3°
ΔGtransfer -24.0 kcal/mol
ΔGfold -15.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 347-371 (343-376)
Pathways

Amoebiasis (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

MAPK signaling pathway (KEGG)

Transcriptional misregulation in cancer (KEGG)

PDB 3o4o (C=14-343)
OPM none
Complexes

IL1R2:IL1AP:IL1B_HUMAN

Interactions

ADA17, Complex: IL1R2:ADA17, PubMed

IL1AP, Complex: IL1AP:IL1B:IL1R2, PDBID: 3O4O, PubMed

Domains

AA: 241-341, PDBID: 3O4O, Subunit C, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for IL1R2_HUMAN » Interleukin-1 receptor type 2
FUNCTION: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

SUBUNIT: Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.

UniProt features for IL1R2_HUMAN » Interleukin-1 receptor type 2
SIGNAL 1 13 Potential.
CHAIN 14 398 Interleukin-1 receptor type 2, membrane form.
CHAIN 14 ? Interleukin-1 receptor type 2, soluble form.
DOMAIN 18 124 Ig-like C2-type 1.
DOMAIN 134 223 Ig-like C2-type 2.
DOMAIN 237 349 Ig-like C2-type 3.
REGION 329 343 Contains proteolytic cleavage site (Probable).
DISULFID 28 116
DISULFID 50 108
DISULFID 152 207
DISULFID 258 326
Amino Acid Sequence for IL1R2_HUMAN » Interleukin-1 receptor type 2
MLRLYVLVMG VSAFTLQPAA HTGAARSCRF RGRHYKREFR LEGEPVALRC PQVPYWLWAS VSPRINLTWH KNDSARTVPG EEETRMWAQD GALWLLPALQ EDSGTYVCTT RNASYCDKMS IELRVFENTD AFLPFISYPQ ILTLSTSGVL VCPDLSEFTR DKTDVKIQWY KDSLLLDKDN EKFLSVRGTT HLLVHDVALE DAGYYRCVLT FAHEGQQYNI TRSIELRIKK KKEETIPVII SPLKTISASL GSRLTIPCKV FLGTGTPLTT MLWWTANDTH IESAYPGGRV TEGPRQEYSE NNENYIEVPL IFDPVTREDL HMDFKCVVHN TLSFQTLRTT VKEASSTFSW GIVLAPLSLA FLVLGGIWMH RRCKHRTGKA DGLTVLWPHH QDFQSYPK