IL1R1_HUMAN » Interleukin-1 receptor type 1

IL1R1_HUMAN » Interleukin-1 receptor type 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL1R1_HUMAN » Interleukin-1 receptor type 1 » IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A;Interleukin-1 receptor alpha;IL-1R-alpha; Interleukin-1 receptor type I;p80;
Hydrophobic Thickness 31.2 ± 3.7 Å
Tilt Angle 26 ± 6°
ΔGtransfer -19.8 kcal/mol
ΔGfold -14.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 338-359 (333-359)
Pathways

Amoebiasis (KEGG)

Apoptosis (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

MAPK signaling pathway (KEGG)

NF-kappa B signaling pathway (KEGG)

Osteoclast differentiation (KEGG)

PDB 4dep (B/E=18-336), 1itb (B=18-332), 4gaf (B=18-336), 1g0y (R=21-332), 1ira (Y=18-336)
OPM none
Complexes

IL1AP:IL1B:IL1R1_HUMAN

Interactions

IL1AP, Complex: IL1R1:IL1AP, PubMed

IL1AP, Complex: IL1AP:IL1B:IL1R1, PDBID: 4DEP

SIGIR, Complex: SIGIR:TRAF6:IL1R1:MYD88:IRAK1, PubMed

TMED7, Complex: IL1R1:TMED7, PubMed

Domains

AA: 49-109, PDBID: 1G0Y, Subunit R, Seq Identity:100%, Immunoglobulin I-set domain

AA: 121-213, PDBID: 1G0Y, Subunit R, Seq Identity:100%, Immunoglobulin domain

AA: 387-564, PDBID: 1T3G, Subunit B, Seq Identity:27%, TIR domain

UniProt annotation for IL1R1_HUMAN » Interleukin-1 receptor type 1
FUNCTION: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

SUBUNIT: The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1.

UniProt features for IL1R1_HUMAN » Interleukin-1 receptor type 1
SIGNAL 1 17
CHAIN 18 569 Interleukin-1 receptor type 1, membrane form.
CHAIN 18 ? Interleukin-1 receptor type 1, soluble form.
DOMAIN 23 110 Ig-like C2-type 1.
DOMAIN 118 210 Ig-like C2-type 2.
DOMAIN 226 328 Ig-like C2-type 3.
DOMAIN 383 541 TIR.
DISULFID 23 104
DISULFID 44 96
DISULFID 121 164
DISULFID 142 196
DISULFID 248 312
Amino Acid Sequence for IL1R1_HUMAN » Interleukin-1 receptor type 1
MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV CSVFIYKIFK IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST SDCDIFVFKV LPEVLEKQCG YKLFIYGRDD YVGEDIVEVI NENVKKSRRL IIILVRETSG FSWLGGSSEE QIAMYNALVQ DGIKVVLLEL EKIQDYEKMP ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV QRRSPSSKHQ LLSPATKEKL QREAHVPLG