IL1AP_HUMAN » Interleukin-1 receptor accessory protein

IL1AP_HUMAN » Interleukin-1 receptor accessory protein
Magnify IL1AP_HUMAN » Interleukin-1 receptor accessory proteinEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL1AP_HUMAN » Interleukin-1 receptor accessory protein » IL-1 receptor accessory protein; IL-1RAcP; Interleukin-1 receptor 3;IL-1R-3; IL-1R3;
Hydrophobic Thickness 28.0 ± 2.0 Å
Tilt Angle 0 ± 1°
ΔGtransfer -41.5 kcal/mol
ΔGfold -20.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 357-381 (357-385)
Pathways

Apoptosis (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Immune System (Reactome)

PDB 3o4o (B=21-350), 4dep (C/F=21-367)
OPM none
Complexes

IL1AP:IL1B:IL1R1_HUMAN

IL1R2:IL1AP:IL1B_HUMAN

Interactions

IL18R, Complex: IL1AP:IL18R, PubMed

IL1R1, Complex: IL1R1:IL1AP, PubMed

IL1R1, Complex: IL1AP:IL1B:IL1R1, PDBID: 4DEP

IL1R2, Complex: IL1AP:IL1B:IL1R2, PDBID: 3O4O, PubMed

SHPS1, Complex: IL1AP:SHPS1, PubMed

TMED7, Complex: IL1AP:TMED7, PubMed

Domains

AA: 242-336, PDBID: 3O4O, Subunit B, Seq Identity:100%, Immunoglobulin domain

AA: 404-570, PDBID: 1T3G, Subunit B, Seq Identity:33%, TIR domain

UniProt annotation for IL1AP_HUMAN » Interleukin-1 receptor accessory protein
FUNCTION: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

SUBUNIT: The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex.

TISSUE SPECIFICITY: Detected in liver, skin, placenta, thymus and lung.

INDUCTION: Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment.

UniProt features for IL1AP_HUMAN » Interleukin-1 receptor accessory protein
SIGNAL 1 20 Potential.
CHAIN 21 570 Interleukin-1 receptor accessory protein.
DOMAIN 21 128 Ig-like C2-type 1.
DOMAIN 141 230 Ig-like C2-type 2.
DOMAIN 242 348 Ig-like C2-type 3.
DOMAIN 403 549 TIR.
DISULFID 24 122
DISULFID 47 114
DISULFID 137 181
DISULFID 160 212
DISULFID 266 332
Amino Acid Sequence for IL1AP_HUMAN » Interleukin-1 receptor accessory protein
MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF EHFLKFNYST AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW FRPTLLNDTG NYTCMLRNTT YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY IEYGIQRITC PNVDGYFPSS VKPTITWYMG CYKIQNFNNV IPEGMNLSFL IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA VPPVIHSPND HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK VPAPRYTVEL ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL DGKEYDIYVS YARNAEEEEF VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV TDETLSFIQK SRRLLVVLSP NYVLQGTQAL LELKAGLENM ASRGNINVIL VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK QLQVAMPVKK SPRRSSSDEQ GLSYSSLKNV