IL18R_HUMAN » Interleukin-18 receptor 1

IL18R_HUMAN » Interleukin-18 receptor 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IL18R_HUMAN » Interleukin-18 receptor 1 » IL-18R-1; IL-18R1; CD218 antigen-like family member A;CDw218a;IL1 receptor-related protein;IL-1Rrp; IL1R-rp;
Hydrophobic Thickness 33.0 ± 1.7 Å
Tilt Angle 4 ± 4°
ΔGtransfer -24.6 kcal/mol
ΔGfold -19.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 331-352 (331-353)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

TNF signaling pathway (KEGG)

PDB 4r6u (A/C=19-329), 3wo3 (B/D...=20-329), 3wo4 (B=20-329)
OPM none
Complexes

I18RA:IL18R:IL18_HUMAN

Interactions

I18RA, Complex: I18RA:IL18R:IL18, PDBID: 3WO4

IL1AP, Complex: IL1AP:IL18R, PubMed

Domains

AA: 375-540, PDBID: 1T3G, Subunit B, Seq Identity:37%, TIR domain

UniProt annotation for IL18R_HUMAN » Interleukin-18 receptor 1
FUNCTION: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

SUBUNIT: Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

TISSUE SPECIFICITY: Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines.

UniProt features for IL18R_HUMAN » Interleukin-18 receptor 1
SIGNAL 1 18
CHAIN 19 541 Interleukin-18 receptor 1.
DOMAIN 33 121 Ig-like C2-type 1.
DOMAIN 133 212 Ig-like C2-type 2.
DOMAIN 220 312 Ig-like C2-type 3.
DOMAIN 373 523 TIR.
DISULFID 140 185 By similarity.
DISULFID 237 298 By similarity.
Amino Acid Sequence for IL18R_HUMAN » Interleukin-18 receptor 1
MNCRELPLTL WVLISVSTAE SCTSRPHITV VEGEPFYLKH CSCSLAHEIE TTTKSWYKSS GSQEHVELNP RSSSRIALHD CVLEFWPVEL NDTGSYFFQM KNYTQKWKLN VIRRNKHSCF TERQVTSKIV EVKKFFQITC ENSYYQTLVN STSLYKNCKK LLLENNKNPT IKKNAEFEDQ GYYSCVHFLH HNGKLFNITK TFNITIVEDR SNIVPVLLGP KLNHVAVELG KNVRLNCSAL LNEEDVIYWM FGEENGSDPN IHEEKEMRIM TPEGKWHASK VLRIENIGES NLNVLYNCTV ASTGGTDTKS FILVRKADMA DIPGHVFTRG MIIAVLILVA VVCLVTVCVI YRVDLVLFYR HLTRRDETLT DGKTYDAFVS YLKECRPENG EEHTFAVEIL PRVLEKHFGY KLCIFERDVV PGGAVVDEIH SLIEKSRRLI IVLSKSYMSN EVRYELESGL HEALVERKIK IILIEFTPVT DFTFLPQSLK LLKSHRVLKW KADKSLSYNS RFWKNLLYLM PAKTVKPGRD EPEVLPVLSE S