IGSF8_HUMAN » Immunoglobulin superfamily member 8

IGSF8_HUMAN » Immunoglobulin superfamily member 8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IGSF8_HUMAN » Immunoglobulin superfamily member 8 » IgSF8; CD81 partner 3;Glu-Trp-Ile EWI motif-containing protein 2;EWI-2; Keratinocytes-associated transmembrane protein 4;KCT-4; LIR-D1;Prostaglandin regulatory-like protein;PGRL;
Hydrophobic Thickness 35.6 ± 5.4 Å
Tilt Angle 40 ± 0°
ΔGtransfer -23.4 kcal/mol
ΔGfold -12.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 577-607 (577-612)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-149, PDBID: 1M71, Subunit B, Seq Identity:23%, Immunoglobulin V-set domain

UniProt annotation for IGSF8_HUMAN » Immunoglobulin superfamily member 8
FUNCTION: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.

SUBUNIT: Interacts directly with CD82, CD81/tetraspanin-28 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1.

TISSUE SPECIFICITY: Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.

DOMAIN: The Ig-like C2-type domains 3 and 4 are required for interaction with CD81.

DOMAIN: The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane localization.

UniProt features for IGSF8_HUMAN » Immunoglobulin superfamily member 8
SIGNAL 1 27
CHAIN 28 613 Immunoglobulin superfamily member 8.
DOMAIN 28 149 Ig-like C2-type 1.
DOMAIN 162 286 Ig-like C2-type 2.
DOMAIN 303 424 Ig-like C2-type 3.
DOMAIN 431 560 Ig-like C2-type 4.
MOTIF 274 276 EWI motif.
DISULFID 49 127 By similarity.
DISULFID 186 270 By similarity.
DISULFID 326 406 By similarity.
DISULFID 462 544 By similarity.
Amino Acid Sequence for IGSF8_HUMAN » Immunoglobulin superfamily member 8
MGALRPTLLP PSLPLLLLLM LGMGCWAREV LVPEGPLYRV AGTAVSISCN VTGYEGPAQQ NFEWFLYRPE APDTALGIVS TKDTQFSYAV FKSRVVAGEV QVQRLQGDAV VLKIARLQAQ DAGIYECHTP STDTRYLGSY SGKVELRVLP DVLQVSAAPP GPRGRQAPTS PPRMTVHEGQ ELALGCLART STQKHTHLAV SFGRSVPEAP VGRSTLQEVV GIRSDLAVEA GAPYAERLAA GELRLGKEGT DRYRMVVGGA QAGDAGTYHC TAAEWIQDPD GSWAQIAEKR AVLAHVDVQT LSSQLAVTVG PGERRIGPGE PLELLCNVSG ALPPAGRHAA YSVGWEMAPA GAPGPGRLVA QLDTEGVGSL GPGYEGRHIA MEKVASRTYR LRLEAARPGD AGTYRCLAKA YVRGSGTRLR EAASARSRPL PVHVREEGVV LEAVAWLAGG TVYRGETASL LCNISVRGGP PGLRLAASWW VERPEDGELS SVPAQLVGGV GQDGVAELGV RPGGGPVSVE LVGPRSHRLR LHSLGPEDEG VYHCAPSAWV QHADYSWYQA GSARSGPVTV YPYMHALDTL FVPLLVGTGV ALVTGATVLG TITCCFMKRL RKR