IGSF6_HUMAN » Immunoglobulin superfamily member 6

IGSF6_HUMAN » Immunoglobulin superfamily member 6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IGSF6_HUMAN » Immunoglobulin superfamily member 6 » IgSF6; Protein DORA;
Hydrophobic Thickness 40.8 ± 1.8 Å
Tilt Angle 10 ± 8°
ΔGtransfer -45.6 kcal/mol
ΔGfold -16.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 153-179 (149-181)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:IGSF6, PubMed

Domains

AA: 39-142, PDBID: 1ZAN, Subunit H, Seq Identity:27%, Immunoglobulin V-set domain

UniProt annotation for IGSF6_HUMAN » Immunoglobulin superfamily member 6
TISSUE SPECIFICITY: Expressed in peripheral blood lymphocytes, spleen and lymph node, with low levels in thymus, bone marrow and fetal liver. No expression in non-immune tissues.

INDUCTION: By TNF and CSF2/GM-CSF in dendritic cells and down regulation by phorbol myristate acetate (PMA) and ionomycin in monocytes.

MISCELLANEOUS: This gene is localized to a locus associated with inflammatory bowel disease. It is coded entirely within the intron of METTL9 which is transcribed in the opposite strand of the DNA.

UniProt features for IGSF6_HUMAN » Immunoglobulin superfamily member 6
SIGNAL 1 27 Potential.
CHAIN 28 241 Immunoglobulin superfamily member 6.
DOMAIN 30 134 Ig-like C2-type.
DISULFID 51 118 By similarity.
Amino Acid Sequence for IGSF6_HUMAN » Immunoglobulin superfamily member 6
MGTASRSNIA RHLQTNLILF CVGAVGACTL SVTQPWYLEV DYTHEAVTIK CTFSATGCPS EQPTCLWFRY GAHQPENLCL DGCKSEADKF TVREALKENQ VSLTVNRVTS NDSAIYICGI AFPSVPEARA KQTGGGTTLV VREIKLLSKE LRSFLTALVS LLSVYVTGVC VAFILLSKSK SNPLRNKEIK EDSQKKKSAR RIFQEIAQEL YHKRHVETNQ QSEKDNNTYE NRRVLSNYER P