|IGSF6_HUMAN » Immunoglobulin superfamily member 6 » IgSF6; Protein DORA;|
|Hydrophobic Thickness||34.4 ± 2.8 Å|
|Tilt Angle||27 ± 7°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||153-179 (149-181)|
|UniProt annotation for IGSF6_HUMAN » Immunoglobulin superfamily member 6|
|TISSUE SPECIFICITY: Expressed in peripheral blood lymphocytes, spleen and lymph node, with low levels in thymus, bone marrow and fetal liver. No expression in non-immune tissues. INDUCTION: By TNF and CSF2/GM-CSF in dendritic cells and down regulation by phorbol myristate acetate (PMA) and ionomycin in monocytes. MISCELLANEOUS: This gene is localized to a locus associated with inflammatory bowel disease. It is coded entirely within the intron of METTL9 which is transcribed in the opposite strand of the DNA.|
|UniProt features for IGSF6_HUMAN » Immunoglobulin superfamily member 6|
SIGNAL 1 27 Potential. |
CHAIN 28 241 Immunoglobulin superfamily member 6.
DOMAIN 30 134 Ig-like C2-type.
DISULFID 51 118 By similarity.
|Amino Acid Sequence for IGSF6_HUMAN » Immunoglobulin superfamily member 6|
|MGTASRSNIA RHLQTNLILF CVGAVGACTL SVTQPWYLEV DYTHEAVTIK CTFSATGCPS EQPTCLWFRY GAHQPENLCL DGCKSEADKF TVREALKENQ VSLTVNRVTS NDSAIYICGI AFPSVPEARA KQTGGGTTLV VREIKLLSKE LRSFLTALVS LLSVYVTGVC VAFILLSKSK SNPLRNKEIK EDSQKKKSAR RIFQEIAQEL YHKRHVETNQ QSEKDNNTYE NRRVLSNYER P|