IGSF5_HUMAN » Immunoglobulin superfamily member 5

IGSF5_HUMAN » Immunoglobulin superfamily member 5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IGSF5_HUMAN » Immunoglobulin superfamily member 5 » IgSF5; Junctional adhesion molecule 4;JAM-4;
Hydrophobic Thickness 32.8 ± 3.0 Å
Tilt Angle 2 ± 1°
ΔGtransfer -13.7 kcal/mol
ΔGfold -3.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 266-287 (266-292)
Pathways

Epithelial cell signaling in Helicobacter pylori infection (KEGG)

Tight junction (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 39-140, PDBID: 1NCT, Subunit A, Seq Identity:21%, Immunoglobulin I-set domain

UniProt annotation for IGSF5_HUMAN » Immunoglobulin superfamily member 5
FUNCTION: Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells (By similarity).

SUBUNIT: Interacts with MAGI1 at tight junctions, forms a tripartite complex with NPHS1. Interacts with LNX1 isoform 2 via its PDZ 2 domain, it may also interact with other isoforms containing this domain.

MISCELLANEOUS: A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.

UniProt features for IGSF5_HUMAN » Immunoglobulin superfamily member 5
CHAIN 1 407 Immunoglobulin superfamily member 5.
DOMAIN 39 139 Ig-like V-type 1.
DOMAIN 142 231 Ig-like V-type 2.
DISULFID 60 123 By similarity.
DISULFID 163 215 By similarity.
Amino Acid Sequence for IGSF5_HUMAN » Immunoglobulin superfamily member 5
MGQKERSTAD TLPDLEEWKS AAGLRWWQTA VVDGSGSGNE VIEGPQNARV LKGSQARFNC TVSQGWKLIM WALSDMVVLS VRPMEPIITN DRFTSQRYDQ GGNFTSEMII HNVEPSDSGN IRCSLQNSRL HGSAYLTVQV MGELFIPSVN LVVAENEPCE VTCLPSHWTR LPDISWELGL LVSHSSYYFV PEPSDLQSAV SILALTPQSN GTLTCVATWK SLKARKSATV NLTVIRCPQD TGGGINIPGV LSSLPSLGFS LPTWGKVGLG LAGTMLLTPT CTLTIRCCCC RRRCCGCNCC CRCCFCCRRK RGFRIQFQKK SEKEKTNKET ETESGNENSG YNSDEQKTTD TASLPPKSCE SSDPEQRNSS CGPPHQRADQ RPPRPASHPQ ASFNLASPEK VSNTTVV