IGSF2_HUMAN » Immunoglobulin superfamily member 2

IGSF2_HUMAN » Immunoglobulin superfamily member 2
Magnify IGSF2_HUMAN » Immunoglobulin superfamily member 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IGSF2_HUMAN » Immunoglobulin superfamily member 2 » IgSF2; Cell surface glycoprotein V7;Glu-Trp-Ile EWI motif-containing protein 101;EWI-101;
Hydrophobic Thickness 35.2 ± 4.4 Å
Tilt Angle 24 ± 6°
ΔGtransfer -31.4 kcal/mol
ΔGfold -26.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 954-980 (952-982)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 26-143, PDBID: 1M71, Subunit B, Seq Identity:22%, Immunoglobulin V-set domain

AA: 151-273, PDBID: 1A2Y, Subunit A, Seq Identity:27%, Immunoglobulin V-set domain

AA: 413-532, PDBID: 2CR6, Subunit A, Seq Identity:22%, Immunoglobulin I-set domain

AA: 820-938, PDBID: 1A2Y, Subunit B, Seq Identity:28%, Immunoglobulin V-set domain

UniProt annotation for IGSF2_HUMAN » Immunoglobulin superfamily member 2
FUNCTION: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.

TISSUE SPECIFICITY: Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.

UniProt features for IGSF2_HUMAN » Immunoglobulin superfamily member 2
SIGNAL 1 20 Potential.
CHAIN 21 1021 Immunoglobulin superfamily member 2.
DOMAIN 22 139 Ig-like C2-type 1.
DOMAIN 144 265 Ig-like C2-type 2.
DOMAIN 279 389 Ig-like C2-type 3.
DOMAIN 408 525 Ig-like C2-type 4.
DOMAIN 541 651 Ig-like C2-type 5.
DOMAIN 656 794 Ig-like C2-type 6.
DOMAIN 808 925 Ig-like C2-type 7.
MOTIF 253 255 EWI motif.
DISULFID 43 121 By similarity.
DISULFID 168 249 By similarity.
DISULFID 304 377 By similarity.
DISULFID 434 511 By similarity.
DISULFID 562 640 By similarity.
DISULFID 697 778 By similarity.
DISULFID 834 909 By similarity.
Amino Acid Sequence for IGSF2_HUMAN » Immunoglobulin superfamily member 2
MAGISYVASF FLLLTKLSIG QREVTVQKGP LFRAEGYPVS IGCNVTGHQG PSEQHFQWSV YLPTNPTQEV QIISTKDAAF SYAVYTQRVR SGDVYVERVQ GNSVLLHISK LQMKDAGEYE CHTPNTDEKY YGSYSAKTNL IVIPDTLSAT MSSQTLGKEE GEPLALTCEA SKATAQHTHL SVTWYLTQDG GGSQATEIIS LSKDFILVPG PLYTERFAAS DVQLNKLGPT TFRLSIERLQ SSDQGQLFCE ATEWIQDPDE TWMFITKKQT DQTTLRIQPA VKDFQVNITA DSLFAEGKPL ELVCLVVSSG RDPQLQGIWF FNGTEIAHID AGGVLGLKND YKERASQGEL QVSKLGPKAF SLKIFSLGPE DEGAYRCVVA EVMKTRTGSW QVLQRKQSPD SHVHLRKPAA RSVVMSTKNK QQVVWEGETL AFLCKAGGAE SPLSVSWWHI PRDQTQPEFV AGMGQDGIVQ LGASYGVPSY HGNTRLEKMD WATFQLEITF TAITDSGTYE CRVSEKSRNQ ARDLSWTQKI SVTVKSLESS LQVSLMSRQP QVMLTNTFDL SCVVRAGYSD LKVPLTVTWQ FQPASSHIFH QLIRITHNGT IEWGNFLSRF QKKTKVSQSL FRSQLLVHDA TEEETGVYQC EVEVYDRNSL YNNRPPRASA ISHPLRIAVT LPESKLKVNS RSQVQELSIN SNTDIECSIL SRSNGNLQLA IIWYFSPVST NASWLKILEM DQTNVIKTGD EFHTPQRKQK FHTEKVSQDL FQLHILNVED SDRGKYHCAV EEWLLSTNGT WHKLGEKKSG LTELKLKPTG SKVRVSKVYW TENVTEHREV AIRCSLESVG SSATLYSVMW YWNRENSGSK LLVHLQHDGL LEYGEEGLRR HLHCYRSSST DFVLKLHQVE MEDAGMYWCR VAEWQLHGHP SKWINQASDE SQRMVLTVLP SEPTLPSRIC SSAPLLYFLF ICPFVLLLLL LISLLCLYWK ARKLSTLRSN TRKEKALWVD LKEAGGVTTN RREDEEEDEG N