IGS11_HUMAN » Immunoglobulin superfamily member 11

IGS11_HUMAN » Immunoglobulin superfamily member 11
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IGS11_HUMAN » Immunoglobulin superfamily member 11 » IgSF11; Brain and testis-specific immunoglobulin superfamily protein;Bt-IGSF; V-set and immunoglobulin domain-containing protein 3;
Hydrophobic Thickness 35.2 ± 4.4 Å
Tilt Angle 2 ± 17°
ΔGtransfer -25.0 kcal/mol
ΔGfold -23.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 245-268 (240-271)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 27-141, PDBID: 1EAJ, Subunit B, Seq Identity:34%, Immunoglobulin V-set domain

AA: 144-219, PDBID: 2OM5, Subunit A, Seq Identity:32%, Immunoglobulin domain

UniProt annotation for IGS11_HUMAN » Immunoglobulin superfamily member 11
FUNCTION: Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.

TISSUE SPECIFICITY: Abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.

MISCELLANEOUS: The last 20 cytoplasmic amino acids are not required for the cell adhesion function.

UniProt features for IGS11_HUMAN » Immunoglobulin superfamily member 11
SIGNAL 1 22 Potential.
CHAIN 23 431 Immunoglobulin superfamily member 11.
DOMAIN 23 136 Ig-like V-type.
DOMAIN 144 234 Ig-like C2-type.
DISULFID 44 120 By similarity.
DISULFID 165 215 By similarity.
Amino Acid Sequence for IGS11_HUMAN » Immunoglobulin superfamily member 11
MTSQRSPLAP LLLLSLHGVA ASLEVSESPG SIQVARGQTA VLPCTFTTSA ALINLNVIWM VTPLSNANQP EQVILYQGGQ MFDGAPRFHG RVGFTGTMPA TNVSIFINNT QLSDTGTYQC LVNNLPDIGG RNIGVTGLTV LVPPSAPHCQ IQGSQDIGSD VILLCSSEEG IPRPTYLWEK LDNTLKLPPT ATQDQVQGTV TIRNISALSS GLYQCVASNA IGTSTCLLDL QVISPQPRNI GLIAGAIGTG AVIIIFCIAL ILGAFFYWRS KNKEEEEEEI PNEIREDDLP PKCSSAKAFH TEISSSDNNT LTSSNAYNSR YWSNNPKVHR NTESVSHFSD LGQSFSFHSG NANIPSIYAN GTHLVPGQHK TLVVTANRGS SPQVMSRSNG SVSRKPRPPH THSYTISHAT LERIGAVPVM VPAQSRAGSL V