IGHD_HUMAN » Ig delta chain C region

IGHD_HUMAN » Ig delta chain C region
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IGHD_HUMAN » Ig delta chain C region »
Hydrophobic Thickness 29.6 ± 5.0 Å
Tilt Angle 44 ± 0°
ΔGtransfer -28.3 kcal/mol
ΔGfold -17.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 399-427 (398-429)
Pathways

Immune System (Reactome)

PDB 1zvo (C/D=1-383)
OPM none
Complexes none
Interactions

CD19, Complex: CD19:IGHD

Domains

AA: 6-91, PDBID: 15C8, Subunit H, Seq Identity:34%, Immunoglobulin C1-set domain

AA: 173-264, PDBID: 4BFI, Subunit B, Seq Identity:20%, Immunoglobulin domain

AA: 278-362, PDBID: 1K8D, Subunit A, Seq Identity:37%, Immunoglobulin C1-set domain

UniProt annotation for IGHD_HUMAN » Ig delta chain C region
FUNCTION: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

SUBUNIT: Immunoglobulin (Ig) molecules consist of two chains, one heavy chain (which can be alpha, delta, epsilon, gamma or mu) and one light chain (which can be kappa or lambda) each consisting of a variable and a constant region. An IgD molecule contains thus a delta heavy chain combined with either a kappa or a lambda light chains. Kappa light chains are found predominantly on the membrane IgD (mIgD) form and lambda on the secreted IgD (sIgD) form, this fact is poorly understood. Membrane-bound IgD molecules are non- covalently associated with a heterodimer of CD79A and CD79B.

MISCELLANEOUS: IgD is not present in every species and this does not relate to phylogeny and evolution. IgD is present in primates, dog, mouse and rat whereas it is undetectable in rabbit, guinea pig, swine, cattle, sheep and Xenopus.

UniProt features for IGHD_HUMAN » Ig delta chain C region
CHAIN <1 384 Ig delta chain C region.
DOMAIN 6 98 Ig-like 1.
DOMAIN 175 263 Ig-like 2.
DOMAIN 267 373 Ig-like 3.
DISULFID 15 15 Interchain (with light chain).
DISULFID 28 84
DISULFID 161 161 Interchain (with heavy chain).
DISULFID 190 249 By similarity.
DISULFID 294 355 By similarity.
Amino Acid Sequence for IGHD_HUMAN » Ig delta chain C region
APTKAPDVFP IISGCRHPKD NSPVVLACLI TGYHPTSVTV TWYMGTQSQP QRTFPEIQRR DSYYMTSSQL STPLQQWRQG EYKCVVQHTA SKSKKEIFRW PESPKAQASS VPTAQPQAEG SLAKATTAPA TTRNTGRGGE EKKKEKEKEE QEERETKTPE CPSHTQPLGV YLLTPAVQDL WLRDKATFTC FVVGSDLKDA HLTWEVAGKV PTGGVEEGLL ERHSNGSQSQ HSRLTLPRSL WNAGTSVTCT LNHPSLPPQR LMALREPAAQ APVKLSLNLL ASSDPPEAAS WLLCEVSGFS PPNILLMWLE DQREVNTSGF APARPPPQPG STTFWAWSVL RVPAPPSPQP ATYTCVVSHE DSRTLLNASR SLEVSYLAMT PLIPQSKDEN SDDYTTFDDV GSLWTTLSTF VALFILTLLY SGIVTFIKVK