IGFR1_HUMAN » IGF-like family receptor 1

IGFR1_HUMAN » IGF-like family receptor 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IGFR1_HUMAN » IGF-like family receptor 1 » Transmembrane protein 149;U2 small nuclear RNA auxiliary factor 1-like 4;
Hydrophobic Thickness 40.8 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -62.3 kcal/mol
ΔGfold -31.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 161-189 (161-189)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for IGFR1_HUMAN » IGF-like family receptor 1
FUNCTION: Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.

INDUCTION: Up-regulated by the proinflammatory cytokine TNFA and in skin upon tissue inflammation.

UniProt features for IGFR1_HUMAN » IGF-like family receptor 1
SIGNAL 1 22 Potential.
CHAIN 23 355 IGF-like family receptor 1.
Amino Acid Sequence for IGFR1_HUMAN » IGF-like family receptor 1
MGPGRCLLTA LLLLALAPPP EASQYCGRLE YWNPDNKCCS SCLQRFGPPP CPDYEFRENC GLNDHGDFVT PPFRKCSSGQ CNPDGAELCS PCGGGAVTPT PAAGGGRTPW RCRERPVPAK GHCPLTPGNP GAPSSQERSS PASSIAWRTP EPVPQQAWPN FLPLVVLVLL LTLAVIAILL FILLWHLCWP KEKADPYPYP GLVCGVPNTH TPSSSHLSSP GALETGDTWK EASLLPLLSR ELSSLASQPL SRLLDELEVL EELIVLLDPE PGPGGGMAHG TTRHLAARYG LPAAWSTFAY SLRPSRSPLR ALIEMVVARE PSASLGQLGT HLAQLGRADA LRVLSKLGSS GVCWA