IEX1_HUMAN » Radiation-inducible immediate-early gene IEX-1

IEX1_HUMAN » Radiation-inducible immediate-early gene IEX-1
Magnify IEX1_HUMAN » Radiation-inducible immediate-early gene IEX-1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IEX1_HUMAN » Radiation-inducible immediate-early gene IEX-1 » Differentiation-dependent gene 2 protein;Protein DIF-2; Immediate early protein GLY96;Immediate early response 3 protein;PACAP-responsive gene 1 protein;Protein PRG1;
Hydrophobic Thickness 30.8 ± 2.0 Å
Tilt Angle 24 ± 0°
ΔGtransfer -22.0 kcal/mol
ΔGfold -9.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 82-103 (82-103)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:IEX1, PubMed

APRIO, Complex: APRIO.PRIO:IEX1, PubMed

MCL1, Complex: IEX1:MCL1, PubMed

TNF10, Complex: TNF10:IEX1, PubMed

TRBM, Complex: IEX1:TRBM, PubMed

Domains none
UniProt annotation for IEX1_HUMAN » Radiation-inducible immediate-early gene IEX-1
FUNCTION: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.

SUBUNIT: Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation.

INDUCTION: By radiation, 12-O-tetradecanoyl phorbol-13 acetate (TPA), okadaic acid, TNF and NUPR1.

UniProt features for IEX1_HUMAN » Radiation-inducible immediate-early gene IEX-1
CHAIN 1 156 Radiation-inducible immediate-early gene IEX-1.
Amino Acid Sequence for IEX1_HUMAN » Radiation-inducible immediate-early gene IEX-1
MCHSRSCHPT MTILQAPTPA PSTIPGPRRG SGPEIFTFDP LPEPAAAPAG RPSASRGHRK RSRRVLYPRV VRRQLPVEEP NPAKRLLFLL LTIVFCQILM AEEGVPAPLP PEDAPNAASL APTPVSPVLE PFNLTSEPSD YALDLSTFLQ QHPAAF