IDD_HUMAN » Integral membrane protein DGCR2/IDD

IDD_HUMAN » Integral membrane protein DGCR2/IDD
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
IDD_HUMAN » Integral membrane protein DGCR2/IDD »
Hydrophobic Thickness 35.2 ± 1.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -47.5 kcal/mol
ΔGfold -18.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 347-372 (342-377)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 28-66, PDBID: 1J8E, Subunit A, Seq Identity:53%, Low-density lipoprotein receptor domain class A

AA: 134-267, PDBID: 1LIT, Subunit A, Seq Identity:20%, Lectin C-type domain

UniProt annotation for IDD_HUMAN » Integral membrane protein DGCR2/IDD
FUNCTION: Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.

TISSUE SPECIFICITY: Predominantly expressed in brain, heart, lung and fetal kidney. Low levels in liver and adult kidney.

UniProt features for IDD_HUMAN » Integral membrane protein DGCR2/IDD
SIGNAL 1 20 Potential.
CHAIN 21 550 Integral membrane protein DGCR2/IDD.
DOMAIN 28 68 LDL-receptor class A.
DOMAIN 115 241 C-type lectin.
DOMAIN 270 333 VWFC.
DISULFID 30 44 By similarity.
DISULFID 37 57 By similarity.
DISULFID 51 66 By similarity.
DISULFID 145 265 By similarity.
DISULFID 233 257 By similarity.
Amino Acid Sequence for IDD_HUMAN » Integral membrane protein DGCR2/IDD
MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACRSG TIQCIPLPWQ CDGWATCEDE SDEANCPEVT GEVRPHHGKE AVDPRQGRAR GGDPSHFHAV NVAQPVRFSS FLGKCPTGWH HYEGTASCYR VYLSGENYWD AAQTCQRLNG SLATFSTDQE LRFVLAQEWD QPERSFGWKD QRKLWVGYQY VITGRNRSLE GRWEVAFKGS SEVFLPPDPI FASAMSENDN VFCAQLQCFH FPTLRHHDLH SWHAESCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL VVSCISSFLI LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD YGPDGFGTGL TPLHLSDDGE GGTFHFHDPP PPYTAYKYPD IGQPDDPPPP YEASIHPDSV FYDPADDDAF EPVEVSLPAP GDGGSEGALL RRLEQPLPTA GASLADLEDS ADSSSALLVP PDPAQSGSTP AAEALPGGGR HSRSSLNTVV