ICOS_HUMAN » Inducible T-cell costimulator

ICOS_HUMAN » Inducible T-cell costimulator
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ICOS_HUMAN » Inducible T-cell costimulator » Activation-inducible lymphocyte immunomediatory molecule;
Hydrophobic Thickness 35.6 ± 0.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -38.9 kcal/mol
ΔGfold -18.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 136-165 (136-172)
Pathways

Cell adhesion molecules (KEGG)

Immune System (Reactome)

Intestinal immune network for IgA production (KEGG)

Primary immunodeficiency (KEGG)

T cell receptor signaling pathway (KEGG)

PDB none
OPM none
Complexes none
Interactions

ICOSL, Complex: ICOSL:ICOS, PubMed

Domains

AA: 23-134, PDBID: 1YJD, Subunit C, Seq Identity:23%, ICOS V-set domain

UniProt annotation for ICOS_HUMAN » Inducible T-cell costimulator
FUNCTION: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

SUBUNIT: Homodimer; disulfide-linked.

TISSUE SPECIFICITY: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.

INDUCTION: By phorbol myristate acetate (PMA) and ionomycin. Up- regulated early on T-cells and continues to be expressed into the later phases of T-cell activation.

DISEASE: Immunodeficiency, common variable, 1 (CVID1) OMIM: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. mutations affecting the gene represented in this entry.

UniProt features for ICOS_HUMAN » Inducible T-cell costimulator
SIGNAL 1 20 Potential.
CHAIN 21 199 Inducible T-cell costimulator.
DOMAIN 30 132 Ig-like V-type.
DISULFID 42 109 By similarity.
DISULFID 63 83 By similarity.
Amino Acid Sequence for ICOS_HUMAN » Inducible T-cell costimulator
MKSGLWYFFL FCLRIKVLTG EINGSANYEM FIFHNGGVQI LCKYPDIVQQ FKMQLLKGGQ ILCDLTKTKG SGNTVSIKSL KFCHSQLSNN SVSFFLYNLD HSHANYYFCN LSIFDPPPFK VTLTGGYLHI YESQLCCQLK FWLPIGCAAF VVVCILGCIL ICWLTKKKYS SSVHDPNGEY MFMRAVNTAK KSRLTDVTL