|ICOS_HUMAN » Inducible T-cell costimulator » Activation-inducible lymphocyte immunomediatory molecule;|
|Hydrophobic Thickness||35.6 ± 0.8 Å|
|Tilt Angle||0 ± 0°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome|
|TM Segments||136-165 (136-172)|
Cell adhesion molecules (KEGG)
Immune System (Reactome)
Primary immunodeficiency (KEGG)
|UniProt annotation for ICOS_HUMAN » Inducible T-cell costimulator|
|FUNCTION: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). SUBUNIT: Homodimer; disulfide-linked. TISSUE SPECIFICITY: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. INDUCTION: By phorbol myristate acetate (PMA) and ionomycin. Up- regulated early on T-cells and continues to be expressed into the later phases of T-cell activation. DISEASE: Immunodeficiency, common variable, 1 (CVID1) OMIM: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. mutations affecting the gene represented in this entry.|
|UniProt features for ICOS_HUMAN » Inducible T-cell costimulator|
SIGNAL 1 20 Potential. |
CHAIN 21 199 Inducible T-cell costimulator.
DOMAIN 30 132 Ig-like V-type.
DISULFID 42 109 By similarity.
DISULFID 63 83 By similarity.
|Amino Acid Sequence for ICOS_HUMAN » Inducible T-cell costimulator|
|MKSGLWYFFL FCLRIKVLTG EINGSANYEM FIFHNGGVQI LCKYPDIVQQ FKMQLLKGGQ ILCDLTKTKG SGNTVSIKSL KFCHSQLSNN SVSFFLYNLD HSHANYYFCN LSIFDPPPFK VTLTGGYLHI YESQLCCQLK FWLPIGCAAF VVVCILGCIL ICWLTKKKYS SSVHDPNGEY MFMRAVNTAK KSRLTDVTL|