ICOSL_HUMAN » ICOS ligand

ICOSL_HUMAN » ICOS ligand
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ICOSL_HUMAN » ICOS ligand » B7 homolog 2;B7-H2; B7-like protein Gl50;B7-related protein 1;B7RP-1;
Hydrophobic Thickness 34.4 ± 2.0 Å
Tilt Angle 0 ± 4°
ΔGtransfer -45.3 kcal/mol
ΔGfold -20.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 254-277 (249-280)
Pathways

Cell adhesion molecules (KEGG)

Immune System (Reactome)

Intestinal immune network for IgA production (KEGG)

PDB none
OPM none
Complexes none
Interactions

ICOS, Complex: ICOSL:ICOS, PubMed

Domains

AA: 20-134, PDBID: 1IGC, Subunit L, Seq Identity:22%, Immunoglobulin V-set domain

AA: 139-225, PDBID: 3BP5, Subunit B, Seq Identity:33%, CD80-like C2-set immunoglobulin domain

UniProt annotation for ICOSL_HUMAN » ICOS ligand
FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity).

TISSUE SPECIFICITY: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.

INDUCTION: Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.

UniProt features for ICOSL_HUMAN » ICOS ligand
SIGNAL 1 18 Potential.
CHAIN 19 302 ICOS ligand.
DOMAIN 19 129 Ig-like V-type.
DOMAIN 141 227 Ig-like C2-type.
DISULFID 37 113 Potential.
DISULFID 158 216 Potential.
Amino Acid Sequence for ICOSL_HUMAN » ICOS ligand
MRLGSPGLLF LLFSSLRADT QEKEVRAMVG SDVELSCACP EGSRFDLNDV YVYWQTSESK TVVTYHIPQN SSLENVDSRY RNRALMSPAG MLRGDFSLRL FNVTPQDEQK FHCLVLSQSL GFQEVLSVEV TLHVAANFSV PVVSAPHSPS QDELTFTCTS INGYPRPNVY WINKTDNSLL DQALQNDTVF LNMRGLYDVV SVLRIARTPS VNIGCCIENV LLQQNLTVGS QTGNDIGERD KITENPVSTG EKNAATWSIL AVLCLLVVVA VAIGWVCRDR CLQHSYAGAW AVSPETELTG HV