ICAM5_HUMAN » Intercellular adhesion molecule 5

ICAM5_HUMAN » Intercellular adhesion molecule 5
Magnify ICAM5_HUMAN » Intercellular adhesion molecule 5Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ICAM5_HUMAN » Intercellular adhesion molecule 5 » ICAM-5; Telencephalin;
Hydrophobic Thickness 36.4 ± 4.8 Å
Tilt Angle 29 ± 25°
ΔGtransfer -13.2 kcal/mol
ΔGfold -11.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 834-862 (834-866)
Pathways none
PDB 4oi9 (32-409), 4oia (32-409), 4oib (32-409), 3bn3 (B=32-227)
OPM none
Complexes

ICAM5:ITAL_HUMAN

Interactions

ITAL, Complex: ICAM5:ITAL, PDBID: 3bn3, PubMed

ITB2, Complex: ICAM5:ITB2, PubMed

Domains

AA: 31-122, PDBID: 3BN3, Subunit B, Seq Identity:100%, Intercellular adhesion molecule (ICAM), N-terminal domain

AA: 670-742, PDBID: 4YFD, Subunit B, Seq Identity:28%, Immunoglobulin domain

AA: 745-818, PDBID: 3ALP, Subunit A, Seq Identity:36%, Immunoglobulin domain

UniProt annotation for ICAM5_HUMAN » Intercellular adhesion molecule 5
FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

TISSUE SPECIFICITY: Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.

UniProt features for ICAM5_HUMAN » Intercellular adhesion molecule 5
SIGNAL 1 31 Potential.
CHAIN 32 924 Intercellular adhesion molecule 5.
DOMAIN 48 130 Ig-like C2-type 1.
DOMAIN 135 235 Ig-like C2-type 2.
DOMAIN 242 329 Ig-like C2-type 3.
DOMAIN 337 402 Ig-like C2-type 4.
DOMAIN 408 486 Ig-like C2-type 5.
DOMAIN 491 568 Ig-like C2-type 6.
DOMAIN 573 662 Ig-like C2-type 7.
DOMAIN 666 739 Ig-like C2-type 8.
DOMAIN 746 830 Ig-like C2-type 9.
DISULFID 55 99
DISULFID 59 103
DISULFID 142 198
DISULFID 249 302 By similarity.
DISULFID 344 383 By similarity.
DISULFID 415 470 By similarity.
DISULFID 498 552 By similarity.
DISULFID 580 645 By similarity.
DISULFID 673 725 By similarity.
DISULFID 769 814 By similarity.
Amino Acid Sequence for ICAM5_HUMAN » Intercellular adhesion molecule 5
MPGPSPGLRR ALLGLWAALG LGLFGLSAVS QEPFWADLQP RVAFVERGGS LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF FRCARRTLQA RGLIRTFQRP DRVELMPLPP WQPVGENFTL SCRVPGAGPR ASLTLTLLRG AQELIRRSFA GEPPRARGAV LTATVLARRE DHGANFSCRA ELDLRPHGLG LFENSSAPRE LRTFSLSPDA PRLAAPRLLE VGSERPVSCT LDGLFPASEA RVYLALGDQN LSPDVTLEGD AFVATATATA SAEQEGARQL VCNVTLGGEN RETRENVTIY SFPAPLLTLS EPSVSEGQMV TVTCAAGAQA LVTLEGVPAA VPGQPAQLQL NATENDDRRS FFCDATLDVD GETLIKNRSA ELRVLYAPRL DDSDCPRSWT WPEGPEQTLR CEARGNPEPS VHCARSDGGA VLALGLLGPV TRALSGTYRC KAANDQGEAV KDVTLTVEYA PALDSVGCPE RITWLEGTEA SLSCVAHGVP PPDVICVRSG ELGAVIEGLL RVAREHAGTY RCEATNPRGS AAKNVAVTVE YGPRFEEPSC PSNWTWVEGS GRLFSCEVDG KPQPSVKCVG SGGTTEGVLL PLAPPDPSPR APRIPRVLAP GIYVCNATNR HGSVAKTVVV SAESPPEMDE STCPSHQTWL EGAEASALAC AARGRPSPGV RCSREGIPWP EQQRVSREDA GTYHCVATNA HGTDSRTVTV GVEYRPVVAE LAASPPGGVR PGGNFTLTCR AEAWPPAQIS WRAPPRALNI GLSSNNSTLS VAGAMGSHGG EYECARTNAH GRHARRITVR VAGPWLWVAV GGAAGGAALL AAGAGLAFYV QSTACKKGEY NVQEAESSGE AVCLNGAGGG AGGAAGAEGG PEAAGGAAES PAEGEVFAIQ LTSA