ICAM4_HUMAN » Intercellular adhesion molecule 4

ICAM4_HUMAN » Intercellular adhesion molecule 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ICAM4_HUMAN » Intercellular adhesion molecule 4 » ICAM-4; Landsteiner-Wiener blood group glycoprotein;LW blood group protein;
Hydrophobic Thickness 34.0 ± 4.8 Å
Tilt Angle 30 ± 14°
ΔGtransfer -16.5 kcal/mol
ΔGfold -15.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 241-268 (236-268)
Pathways

Immune System (Reactome)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

CREB3, Complex: ICAM4:CREB3

ITA2B, Complex: ICAM4:ITB3:ITA2B

ITA4, Complex: ICAM4:ITA4, PubMed

ITAL, Complex: ITAL:ICAM4:ITB2

ITAM, Complex: ITAM:ICAM4, PubMed

ITAV, Complex: ITAV:ICAM4:ITB5, PubMed

ITB1, Complex: ICAM4:ITB1, PubMed

ITB2, Complex: ITB2:ICAM4, PubMed

Domains

AA: 46-136, PDBID: 3BN3, Subunit B, Seq Identity:37%, Intercellular adhesion molecule (ICAM), N-terminal domain

UniProt annotation for ICAM4_HUMAN » Intercellular adhesion molecule 4
FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.

TISSUE SPECIFICITY: Erythrocytes.

UniProt features for ICAM4_HUMAN » Intercellular adhesion molecule 4
SIGNAL 1 22 Potential.
CHAIN 23 271 Intercellular adhesion molecule 4.
DOMAIN 62 124 Ig-like C2-type 1.
DOMAIN 146 217 Ig-like C2-type 2.
DISULFID 69 117 By similarity.
DISULFID 153 210 By similarity.
Amino Acid Sequence for ICAM4_HUMAN » Intercellular adhesion molecule 4
MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQSPKGSPLA PSGTSVPFWV RMSPEFVAVQ PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LRGPGWVSYQ LLDVRAWSSL AHCLVTCAGK TRWATSRITA YKPPHSVILE PPVLKGRKYT LRCHVTQVFP VGYLVVTLRH GSRVIYSESL ERFTGLDLAN VTLTYEFAAG PRDFWQPVIC HARLNLDGLV VRNSSAPITL MLAWSPAPTA LASGSIAALV GILLTVGAAY LCKCLAMKSQ A