ICAM3_HUMAN » Intercellular adhesion molecule 3

ICAM3_HUMAN » Intercellular adhesion molecule 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ICAM3_HUMAN » Intercellular adhesion molecule 3 » ICAM-3; CDw50;ICAM-R;
Hydrophobic Thickness 34.4 ± 1.8 Å
Tilt Angle 30 ± 4°
ΔGtransfer -32.9 kcal/mol
ΔGfold -22.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 486-510 (486-516)
Pathways

Cell adhesion molecules (KEGG)

Immune System (Reactome)

Signal Transduction (Reactome)

PDB 1t0p (B=30-114)
OPM none
Complexes

ICAM3:ITAL_HUMAN

Interactions

A4, Complex: ICAM3:A4, PubMed

CD209, Complex: CD209:ICAM3, PubMed

CLC4M, Complex: CLC4M:ICAM3, PubMed

ITAD, Complex: ITAD:ICAM3, PubMed

ITAL, Complex: ICAM3:ITAL, PDBID: 1t0p, PubMed

ITB2, Complex: ITB2:ICAM3, PubMed

Domains

AA: 29-119, PDBID: 1T0P, Subunit B, Seq Identity:100%, Intercellular adhesion molecule (ICAM), N-terminal domain

UniProt annotation for ICAM3_HUMAN » Intercellular adhesion molecule 3
FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.
UniProt features for ICAM3_HUMAN » Intercellular adhesion molecule 3
SIGNAL 1 29 Potential.
CHAIN 30 547 Intercellular adhesion molecule 3.
DOMAIN 46 103 Ig-like C2-type 1.
DOMAIN 132 197 Ig-like C2-type 2.
DOMAIN 234 301 Ig-like C2-type 3.
DOMAIN 329 382 Ig-like C2-type 4.
DOMAIN 416 469 Ig-like C2-type 5.
DISULFID 53 96
DISULFID 139 190 Potential.
DISULFID 241 294 Potential.
DISULFID 336 375 Potential.
DISULFID 423 462 Potential.
Amino Acid Sequence for ICAM3_HUMAN » Intercellular adhesion molecule 3
MATMVPSVLW PRACWTLLVC CLLTPGVQGQ EFLLRVEPQN PVLSAGGSLF VNCSTDCPSS EKIALETSLS KELVASGMGW AAFNLSNVTG NSRILCSVYC NGSQITGSSN ITVYRLPERV ELAPLPPWQP VGQNFTLRCQ VEDGSPRTSL TVVLLRWEEE LSRQPAVEEP AEVTATVLAS RDDHGAPFSC RTELDMQPQG LGLFVNTSAP RQLRTFVLPV TPPRLVAPRF LEVETSWPVD CTLDGLFPAS EAQVYLALGD QMLNATVMNH GDTLTATATA TARADQEGAR EIVCNVTLGG ERREARENLT VFSFLGPIVN LSEPTAHEGS TVTVSCMAGA RVQVTLDGVP AAAPGQPAQL QLNATESDDG RSFFCSATLE VDGEFLHRNS SVQLRVLYGP KIDRATCPQH LKWKDKTRHV LQCQARGNPY PELRCLKEGS SREVPVGIPF FVNVTHNGTY QCQASSSRGK YTLVVVMDIE AGSSHFVPVF VAVLLTLGVV TIVLALMYVF REHQRSGSYH VREESTYLPL TSMQPTEAMG EEPSRAE