ICAM2_HUMAN » Intercellular adhesion molecule 2

ICAM2_HUMAN » Intercellular adhesion molecule 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ICAM2_HUMAN » Intercellular adhesion molecule 2 » ICAM-2;
Hydrophobic Thickness 41.2 ± 2.8 Å
Tilt Angle 9 ± 2°
ΔGtransfer -56.0 kcal/mol
ΔGfold -21.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 221-249 (221-255)
Pathways

Cell adhesion molecules (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Signal Transduction (Reactome)

PDB 1zxq (A=25-216)
OPM none
Complexes none
Interactions

CD209, Complex: CD209:ICAM2, PubMed

CD44, Complex: CD44:ICAM2:RADI:LEUK, PubMed

ITAM, Complex: ICAM2:ITAM, PubMed

ITB2, Complex: ITB2:ICAM2, PubMed

Domains

AA: 24-114, PDBID: 1ZXQ, Subunit A, Seq Identity:100%, Intercellular adhesion molecule (ICAM), N-terminal domain

UniProt annotation for ICAM2_HUMAN » Intercellular adhesion molecule 2
FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
UniProt features for ICAM2_HUMAN » Intercellular adhesion molecule 2
SIGNAL 1 24
CHAIN 25 275 Intercellular adhesion molecule 2.
DOMAIN 41 98 Ig-like C2-type 1.
DOMAIN 127 197 Ig-like C2-type 2.
DISULFID 48 91
DISULFID 52 95
DISULFID 134 190
Amino Acid Sequence for ICAM2_HUMAN » Intercellular adhesion molecule 2
MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF RGNETLHYET FGKAAPAPQE ATATFNSTAD REDGHRNFSC LAVLDLMSRG GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT SVLLCFIFGQ HLRQQRMGTY GVRAAWRRLP QAFRP