ICAM1_HUMAN » Intercellular adhesion molecule 1

ICAM1_HUMAN » Intercellular adhesion molecule 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ICAM1_HUMAN » Intercellular adhesion molecule 1 » ICAM-1; Major group rhinovirus receptor;
Hydrophobic Thickness 28.8 ± 1.8 Å
Tilt Angle 7 ± 3°
ΔGtransfer -36.6 kcal/mol
ΔGfold -18.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 479-502 (477-507)
Pathways

African trypanosomiasis (KEGG)

Cell adhesion molecules (KEGG)

Epstein-Barr virus infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Influenza A (KEGG)

Leukocyte transendothelial migration (KEGG)

Malaria (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

NF-kappa B signaling pathway (KEGG)

Rheumatoid arthritis (KEGG)

Signal Transduction (Reactome)

Staphylococcus aureus infection (KEGG)

TNF signaling pathway (KEGG)

Viral myocarditis (KEGG)

PDB 1p53 (212-477), 1d3e (28-212), 1d3i (28-212), 1d3l (28-212), 1z7z (28-477), 1ic1 (A/B=28-217), 3tcx (A/C...=29-112), 1mq8 (A/C=28-318), 2oz4 (A=213-477), 1iam (A=28-212)
OPM none
Complexes

ICAM1:ITAL_HUMAN

Interactions

3BHS7, Complex: 3BHS7:ICAM1, PubMed

4F2, Complex: LAT2:ICAM1:4F2, PubMed

CSF2R, Complex: ICAM1:CSF2R:PTN11:IL3RB:FYN, PubMed

EGFR, Complex: ICAM1:EGFR, PubMed

IL2RA, Complex: IL2RA:ICAM1, PubMed

IL2RG, Complex: IL2RG:ICAM1, PubMed

ITAL, Complex: ICAM1:ITAL, PDBID: 1mq8, PubMed

ITAM, Complex: ITAM:ICAM1, PubMed

ITB2, Complex: ITB2:ICAM1, PubMed

LEUK, Complex: LEUK:ICAM1, PubMed

Domains

AA: 24-115, PDBID: 1IAM, Subunit A, Seq Identity:100%, Intercellular adhesion molecule (ICAM), N-terminal domain

UniProt annotation for ICAM1_HUMAN » Intercellular adhesion molecule 1
FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

SUBUNIT: Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.

UniProt features for ICAM1_HUMAN » Intercellular adhesion molecule 1
SIGNAL 1 27
CHAIN 28 532 Intercellular adhesion molecule 1.
DOMAIN 41 103 Ig-like C2-type 1.
DOMAIN 128 193 Ig-like C2-type 2.
DOMAIN 230 297 Ig-like C2-type 3.
DOMAIN 325 378 Ig-like C2-type 4.
DOMAIN 412 464 Ig-like C2-type 5.
MOTIF 152 154 Cell attachment site; atypical (Potential).
DISULFID 48 92
DISULFID 52 96
DISULFID 135 186
DISULFID 237 290
DISULFID 332 371
DISULFID 403 419
DISULFID 431 457
Amino Acid Sequence for ICAM1_HUMAN » Intercellular adhesion molecule 1
MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPSKVILPR GGSVLVTCST SCDQPKLLGI ETPLPKKELL LPGNNRKVYE LSNVQEDSQP MCYSNCPDGQ STAKTFLTVY WTPERVELAP LPSWQPVGKN LTLRCQVEGG APRANLTVVL LRGEKELKRE PAVGEPAEVT TTVLVRRDHH GANFSCRTEL DLRPQGLELF ENTSAPYQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD GLFPVSEAQV HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQRLTC AVILGNQSQE TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPL GPRAQLLLKA TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE RDCPGNWTWP ENSQQTPMCQ AWGNPLPELK CLKDGTFPLP IGESVTVTRD LEGTYLCRAR STQGEVTRKV TVNVLSPRYE IVIITVVAAA VIMGTAGLST YLYNRQRKIK KYRLQQAQKG TPMKPNTQAT PP