I27RA_HUMAN » Interleukin-27 receptor subunit alpha

I27RA_HUMAN » Interleukin-27 receptor subunit alpha
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I27RA_HUMAN » Interleukin-27 receptor subunit alpha » IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; Cytokine receptor WSX-1;Cytokine receptor-like 1;Type I T-cell cytokine receptor;TCCR; ZcytoR1;
Hydrophobic Thickness 34.4 ± 3.0 Å
Tilt Angle 5 ± 2°
ΔGtransfer -23.1 kcal/mol
ΔGfold -12.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 513-537 (510-547)
Pathways none
PDB none
OPM none
Complexes none
Interactions

GOSR1, Complex: I27RA:GOSR1, PubMed

Domains

AA: 321-406, PDBID: 2EKJ, Subunit A, Seq Identity:30%, Fibronectin type III domain

UniProt annotation for I27RA_HUMAN » Interleukin-27 receptor subunit alpha
FUNCTION: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms.

TISSUE SPECIFICITY: Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B- cells and monocytes.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

UniProt features for I27RA_HUMAN » Interleukin-27 receptor subunit alpha
SIGNAL 1 32 Potential.
CHAIN 33 636 Interleukin-27 receptor subunit alpha.
DOMAIN 135 228 Fibronectin type-III 1.
DOMAIN 319 411 Fibronectin type-III 2.
DOMAIN 416 507 Fibronectin type-III 3.
MOTIF 217 221 WSXWS motif.
MOTIF 554 562 Box 1 motif.
Amino Acid Sequence for I27RA_HUMAN » Interleukin-27 receptor subunit alpha
MRGGRGAPFW LWPLPKLALL PLLWVLFQRT RPQGSAGPLQ CYGVGPLGDL NCSWEPLGDL GAPSELHLQS QKYRSNKTQT VAVAAGRSWV AIPREQLTMS DKLLVWGTKA GQPLWPPVFV NLETQMKPNA PRLGPDVDFS EDDPLEATVH WAPPTWPSHK VLICQFHYRR CQEAAWTLLE PELKTIPLTP VEIQDLELAT GYKVYGRCRM EKEEDLWGEW SPILSFQTPP SAPKDVWVSG NLCGTPGGEE PLLLWKAPGP CVQVSYKVWF WVGGRELSPE GITCCCSLIP SGAEWARVSA VNATSWEPLT NLSLVCLDSA SAPRSVAVSS IAGSTELLVT WQPGPGEPLE HVVDWARDGD PLEKLNWVRL PPGNLSALLP GNFTVGVPYR ITVTAVSASG LASASSVWGF REELAPLVGP TLWRLQDAPP GTPAIAWGEV PRHQLRGHLT HYTLCAQSGT SPSVCMNVSG NTQSVTLPDL PWGPCELWVT ASTIAGQGPP GPILRLHLPD NTLRWKVLPG ILFLWGLFLL GCGLSLATSG RCYHLRHKVL PRWVWEKVPD PANSSSGQPH MEQVPEAQPL GDLPILEVEE MEPPPVMESS QPAQATAPLD SGYEKHFLPT PEELGLLGPP RPQVLA