I22R1_HUMAN » Interleukin-22 receptor subunit alpha-1

I22R1_HUMAN » Interleukin-22 receptor subunit alpha-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I22R1_HUMAN » Interleukin-22 receptor subunit alpha-1 » IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; Cytokine receptor class-II member 9;Cytokine receptor family 2 member 9;CRF2-9; ZcytoR11;
Hydrophobic Thickness 28.4 ± 1.8 Å
Tilt Angle 0 ± 1°
ΔGtransfer -36.5 kcal/mol
ΔGfold -16.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 226-251 (223-256)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Jak-STAT signaling pathway (KEGG)

PDB 3dgc (R/S=17-226), 3dlq (R=18-228)
OPM none
Complexes none
Interactions

I20RB, Complex: IL24:I20RB:I22R1, PubMed

Domains

AA: 2-107, PDBID: 3DGC, Subunit R, Seq Identity:100%, Tissue factor

AA: 119-214, PDBID: 3DGC, Subunit R, Seq Identity:100%, Interferon-alpha/beta receptor, fibronectin type III

UniProt annotation for I22R1_HUMAN » Interleukin-22 receptor subunit alpha-1
FUNCTION: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

SUBUNIT: Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.

TISSUE SPECIFICITY: Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.

INDUCTION: By IFNG/IFN-gamma in keratinocytes.

MISCELLANEOUS: Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1.

UniProt features for I22R1_HUMAN » Interleukin-22 receptor subunit alpha-1
SIGNAL 1 15 Potential.
CHAIN 16 574 Interleukin-22 receptor subunit alpha-1.
DOMAIN 18 115 Fibronectin type-III 1.
DOMAIN 141 221 Fibronectin type-III 2.
DISULFID 71 79
DISULFID 128 217
Amino Acid Sequence for I22R1_HUMAN » Interleukin-22 receptor subunit alpha-1
MRTLLTILTV GSLAAHAPED PSDLLQHVKF QSSNFENILT WDSGPEGTPD TVYSIEYKTY GERDWVAKKG CQRITRKSCN LTVETGNLTE LYYARVTAVS AGGRSATKMT DRFSSLQHTT LKPPDVTCIS KVRSIQMIVH PTPTPIRAGD GHRLTLEDIF HDLFYHLELQ VNRTYQMHLG GKQREYEFFG LTPDTEFLGT IMICVPTWAK ESAPYMCRVK TLPDRTWTYS FSGAFLFSMG FLVAVLCYLS YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS YAPNAAPEVG PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP PSYGVCMEGS GKDSPTGTLS SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV TSLAMEESQE AKSLHQPLGI CTDRTSDPNV LHSGEEGTPQ YLKGQLPLLS SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK DEAKSPAPET SDLEQPTELD SLFRGLALTV QWES