I20RB_HUMAN » Interleukin-20 receptor subunit beta

I20RB_HUMAN » Interleukin-20 receptor subunit beta
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I20RB_HUMAN » Interleukin-20 receptor subunit beta » IL-20 receptor subunit beta; IL-20R-beta; IL-20RB; IL-20R2;
Hydrophobic Thickness 36.0 ± 3.6 Å
Tilt Angle 28 ± 0°
ΔGtransfer -34.7 kcal/mol
ΔGfold -26.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 230-257 (230-257)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Jak-STAT signaling pathway (KEGG)

PDB 4doh (B/D=30-231)
OPM none
Complexes

I20RB:IL20:I20RA_HUMAN

Interactions

I20RA, Complex: IL20:I20RA:I20RB, PDBID: 4doh, PubMed

I22R1, Complex: IL24:I20RB:I22R1, PubMed

Domains

AA: 15-124, PDBID: 4DOH, Subunit B, Seq Identity:100%, Tissue factor

AA: 136-227, PDBID: 4DOH, Subunit D, Seq Identity:100%, Interferon-alpha/beta receptor, fibronectin type III

UniProt annotation for I20RB_HUMAN » Interleukin-20 receptor subunit beta
FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

SUBUNIT: Heterodimer with IL20RA and heterodimer with IL22RA1.

TISSUE SPECIFICITY: Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin.

UniProt features for I20RB_HUMAN » Interleukin-20 receptor subunit beta
SIGNAL 1 29
CHAIN 30 311 Interleukin-20 receptor subunit beta.
DOMAIN 36 137 Fibronectin type-III 1.
DOMAIN 144 228 Fibronectin type-III 2.
DISULFID 202 223 By similarity.
Amino Acid Sequence for I20RB_HUMAN » Interleukin-20 receptor subunit beta
MQTFTMVLEE IWTSLFMWFF YALIPCLLTD EVAILPAPQN LSVLSTNMKH LLMWSPVIAP GETVYYSVEY QGEYESLYTS HIWIPSSWCS LTEGPECDVT DDITATVPYN LRVRATLGSQ TSAWSILKHP FNRNSTILTR PGMEITKDGF HLVIELEDLG PQFEFLVAYW RREPGAEEHV KMVRSGGIPV HLETMEPGAA YCVKAQTFVK AIGRYSAFSQ TECVEVQGEA IPLVLALFAF VGFMLILVVV PLFVWKMGRL LQYSCCPVVV LPDTLKITNS PQKLISCRRE EVDACATAVM SPEELLRAWI S