I20RA_HUMAN » Interleukin-20 receptor subunit alpha

I20RA_HUMAN » Interleukin-20 receptor subunit alpha
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I20RA_HUMAN » Interleukin-20 receptor subunit alpha » IL-20 receptor subunit alpha; IL-20R-alpha; IL-20RA; Cytokine receptor class-II member 8;Cytokine receptor family 2 member 8;CRF2-8; IL-20R1;ZcytoR7;
Hydrophobic Thickness 32.8 ± 4.4 Å
Tilt Angle 36 ± 5°
ΔGtransfer -25.0 kcal/mol
ΔGfold -18.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 248-274 (245-278)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Jak-STAT signaling pathway (KEGG)

PDB 4doh (E/R=29-245)
OPM none
Complexes

I20RB:IL20:I20RA_HUMAN

Interactions

I20RB, Complex: IL20:I20RA:I20RB, PDBID: 4doh, PubMed

Domains

AA: 14-123, PDBID: 4DOH, Subunit E, Seq Identity:100%, Tissue factor

AA: 135-240, PDBID: 4DOH, Subunit E, Seq Identity:100%, Interferon-alpha/beta receptor, fibronectin type III

UniProt annotation for I20RA_HUMAN » Interleukin-20 receptor subunit alpha
FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

SUBUNIT: Heterodimer with IL20RB and heterodimer with IL10RB.

TISSUE SPECIFICITY: Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.

UniProt features for I20RA_HUMAN » Interleukin-20 receptor subunit alpha
SIGNAL 1 29
CHAIN 30 553 Interleukin-20 receptor subunit alpha.
DOMAIN 37 136 Fibronectin type-III 1.
DOMAIN 138 237 Fibronectin type-III 2.
DISULFID 87 95 By similarity.
DISULFID 215 236 By similarity.
Amino Acid Sequence for I20RA_HUMAN » Interleukin-20 receptor subunit alpha
MRAPGRPALR PLPLPPLLLL LLAAPWGRAV PCVSGGLPKP ANITFLSINM KNVLQWTPPE GLQGVKVTYT VQYFIYGQKK WLNKSECRNI NRTYCDLSAE TSDYEHQYYA KVKAIWGTKC SKWAESGRFY PFLETQIGPP EVALTTDEKS ISVVLTAPEK WKRNPEDLPV SMQQIYSNLK YNVSVLNTKS NRTWSQCVTN HTLVLTWLEP NTLYCVHVES FVPGPPRRAQ PSEKQCARTL KDQSSEFKAK IIFWYVLPVS ITVFLFSVMG YSIYRYIHVG KEKHPANLIL IYGNEFDKRF FVPAEKIVIN FITLNISDDS KISHQDMSLL GKSSDVSSLN DPQPSGNLRP PQEEEEVKHL GYASHLMEIF CDSEENTEGT SLTQQESLSR TIPPDKTVIE YEYDVRTTDI CAGPEEQELS LQEEVSTQGT LLESQAALAV LGPQTLQYSY TPQLQDLDPL AQEHTDSEEG PEEEPSTTLV DWDPQTGRLC IPSLSSFDQD SEGCEPSEGD GLGEEGLLSR LYEEPAPDRP PGENETYLMQ FMEEWGLYVQ MEN