I18RA_HUMAN » Interleukin-18 receptor accessory protein

I18RA_HUMAN » Interleukin-18 receptor accessory protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I18RA_HUMAN » Interleukin-18 receptor accessory protein » IL-18 receptor accessory protein; IL-18RAcP; Accessory protein-like;AcPL; CD218 antigen-like family member B;CDw218b;IL-1R accessory protein-like;IL-1RAcPL; Interleukin-1 receptor 7;IL-1R-7; IL-1R7; Interleukin-18 receptor accessory protein-like;Interleuk
Hydrophobic Thickness 34.8 ± 4.6 Å
Tilt Angle 48 ± 8°
ΔGtransfer -23.3 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 358-386 (358-395)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB 3wo4 (C=15-356)
OPM none
Complexes

I18RA:IL18R:IL18_HUMAN

Interactions

A4, Complex: I18RA:A4, PubMed

IL18R, Complex: I18RA:IL18R:IL18, PDBID: 3WO4

Domains

AA: 154-242, PDBID: 3WO4, Subunit C, Seq Identity:100%, Immunoglobulin domain

AA: 410-597, PDBID: 1T3G, Subunit B, Seq Identity:33%, TIR domain

UniProt annotation for I18RA_HUMAN » Interleukin-18 receptor accessory protein
FUNCTION: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.

SUBUNIT: Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18.

TISSUE SPECIFICITY: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.

INDUCTION: Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells.

UniProt features for I18RA_HUMAN » Interleukin-18 receptor accessory protein
SIGNAL 1 19 Potential.
CHAIN 20 599 Interleukin-18 receptor accessory protein.
DOMAIN 149 235 Ig-like C2-type 1.
DOMAIN 251 353 Ig-like C2-type 2.
DOMAIN 406 562 TIR.
DISULFID 180 221 By similarity.
DISULFID 273 337 By similarity.
Amino Acid Sequence for I18RA_HUMAN » Interleukin-18 receptor accessory protein
MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE PQKSHFCHRN RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS YPHIIQDKCT LHFLTPGVNN SGSYICRPKM IKSPYDVACC VKMILEVKPQ TNASCEYSAS HKQDLLLGST GSISCPSLSC QSDAQSPAVT WYKNGKLLSV ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV RTIVGDTKLK PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV QLKEKRGVVL LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ TLGDKKDFDA FVSYAKWSSF PSEATSSLSE EHLALSLFPD VLENKYGYSL CLLERDVAPG GVYAEDIVSI IKRSRRGIFI LSPNYVNGPS IFELQAAVNL ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR GLKSVPPNSR FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW