I17RE_HUMAN » Interleukin-17 receptor E

I17RE_HUMAN » Interleukin-17 receptor E
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
I17RE_HUMAN » Interleukin-17 receptor E » IL-17 receptor E; IL-17RE;
Hydrophobic Thickness 34.8 ± 1.3 Å
Tilt Angle 2 ± 1°
ΔGtransfer -26.5 kcal/mol
ΔGfold -25.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 455-477 (449-479)
Pathways none
PDB none
OPM none
Complexes none
Interactions

I17RA, Complex: I17RA:I17RE, PubMed

Domains

AA: 39-448, Interleukin-17 receptor extracellular region

AA: 488-567, PDBID: 4NUX, Subunit A, Seq Identity:12%, SEFIR domain

AA: 577-626, PDBID: 3VBC, Subunit A, Seq Identity:7%, SEFIR domain

UniProt annotation for I17RE_HUMAN » Interleukin-17 receptor E
FUNCTION: Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

SUBUNIT: Forms heterodimers with IL17RA; the heterodimer binds IL17C.

TISSUE SPECIFICITY: Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.

UniProt features for I17RE_HUMAN » Interleukin-17 receptor E
SIGNAL 1 23 Potential.
CHAIN 24 667 Interleukin-17 receptor E.
DOMAIN 487 624 SEFIR.
Amino Acid Sequence for I17RE_HUMAN » Interleukin-17 receptor E
MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG SSAYIPCRTW WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV QKSKKSSTFK FYRRHKMPAP AQRKLLPRRH LSEKSHHISI PSPDISHKGL RSKRTQPSDP ETWESLPRLD SQRHGGPEFS FDLLPEARAI RVTISSGPEV SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP CLCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH VECPHQTGSL TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL VPPVYTVSQA RGSSPVSLDL IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV SYRHLGLLIL ALLALLTLLG VVLALTCRRP QSGPGPARPV LLLHAADSEA QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW LWAARTRVAR EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL ELCSRLEREA ARLADLG